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Vol.57 (2011) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/301

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Title: Effect of additional administration of tacrolimus in patients with rheumatoid arthritis treated with biologics
Other Titles: Coadministration of tacrolimus to biologics
Authors: Miyata, Masayuki
Asano, Tomoyuki
Satoh, Shuzo
Affiliation: 消化器・リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 57
Issue: 2
Start page: 54
End page: 59
Issue Date: 2011
Abstract: OBJECTIVE: To explore the effect of additional administration of tacrolimus to rheumatoid arthritis patients treated with biologics, in whom the effect of biologics is unsatisfactory. METHODS: Tacrolimus was administered if the effect of biologics was unsatisfactory for 24 weeks at least in terms of laboratory data or DAS28 level: ESR, CRP level and DAS28 level were not below 15 mm/h, 0.2 mg/dl or 2.6, respectively. RESULTS: Tacrolimus administered in addition to biologics was significantly effective for suppressing the activity of rheumatoid arthritis in our study. The significant effect of tacrolimus appeared at the 4th week. The effect of tacrolimus achieved quite significant level at the 54th week (p< 0.0001). CONCLUSION: Tacrolimus may be a promising candidate to suppress the disease activity of rheumatoid arthritis refractory to the conventional treatment with biologics.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/301
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/301/1/FksmJMedSci_57_p54.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.57.54
PubMed ID: 22353651
Other version: http://dx.doi.org/10.5387/fms.57.54
Rights: © 2011 The Fukushima Society of Medical Science
Appears in Collections:Vol.57 (2011)

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