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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.57 (2011) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/301
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| タイトル: | Effect of additional administration of tacrolimus in patients with rheumatoid arthritis treated with biologics |
| その他のタイトル: | Coadministration of tacrolimus to biologics |
| 著者: | Miyata, Masayuki
Asano, Tomoyuki
Satoh, Shuzo |
| 学内所属: | 消化器・リウマチ膠原病内科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 57 |
| 号: | 2 |
| 開始ページ: | 54 |
| 終了ページ: | 59 |
| 発行日: | 2011年 |
| 抄録: | OBJECTIVE: To explore the effect of additional administration of tacrolimus to rheumatoid arthritis patients treated with biologics, in whom the effect of biologics is unsatisfactory. METHODS: Tacrolimus was administered if the effect of biologics was unsatisfactory for 24 weeks at least in terms of laboratory data or DAS28 level: ESR, CRP level and DAS28 level were not below 15 mm/h, 0.2 mg/dl or 2.6, respectively. RESULTS: Tacrolimus administered in addition to biologics was significantly effective for suppressing the activity of rheumatoid arthritis in our study. The significant effect of tacrolimus appeared at the 4th week. The effect of tacrolimus achieved quite significant level at the 54th week (p< 0.0001). CONCLUSION: Tacrolimus may be a promising candidate to suppress the disease activity of rheumatoid arthritis refractory to the conventional treatment with biologics. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/301 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/301/1/FksmJMedSci_57_p54.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.57.54 |
| PubMed番号: | 22353651 |
| 異版(出版者版等): | http://dx.doi.org/10.5387/fms.57.54 |
| 権利情報: | © 2011 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.57 (2011)
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