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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.57 (2011) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/300
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| タイトル: | A comparison of pain-related behavior following local application of nucleus pulposus and/or mechanical compression on the dorsal root ganglion |
| その他のタイトル: | Pain behavior of chemical or mechanical factors |
| 著者: | Sasaki, Nobuhisa
Sekiguchi, Miho
Shishido, Hiroaki
Kikuchi, Shin-ichi
Yabuki, Shoji
Konno, Shin-ichi |
| 学内所属: | 整形外科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 57 |
| 号: | 2 |
| 開始ページ: | 46 |
| 終了ページ: | 53 |
| 発行日: | 2011年 |
| 抄録: | Symptomatic induction of disc herniation involves both mechanical compression and chemical factors. Inhibitors of tumor necrosis factor-alpha (TNF-α) are known to reduce pain-related behavior in experimental models. Animals were divided into mechanical compression (MC) group; a stainless steel rod was inserted on the dorsal root ganglion, nucleus pulposus (NP) group: NP was harvested from the coccygeal vertebral disc, MC and NP group; rats were received stainless rod and NP, and sham group; rats were received neither rod nor NP. Rats in the MC group received a TNF-α antibody (10 mg/kg) (antibody group) or were not treatment (untreated group). The withdrawal thresholds of the MC, NP and MC+NP groups decreased significantly compared with the sham group. In the antibody group, the threshold was significantly higher than that of the untreated group. An anti-TNF-α antibody reduced allodynia caused by DRG compression. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/300 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/300/1/FksmJMedSci_57_p46.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.57.46 |
| PubMed番号: | 22353650 |
| 異版(出版者版等): | http://dx.doi.org/10.5387/fms.57.46 |
| 権利情報: | © 2011 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.57 (2011)
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