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Vol.57 (2011) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/300

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Title: A comparison of pain-related behavior following local application of nucleus pulposus and/or mechanical compression on the dorsal root ganglion
Other Titles: Pain behavior of chemical or mechanical factors
Authors: Sasaki, Nobuhisa
Sekiguchi, Miho
Shishido, Hiroaki
Kikuchi, Shin-ichi
Yabuki, Shoji
Konno, Shin-ichi
Affiliation: 整形外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 57
Issue: 2
Start page: 46
End page: 53
Issue Date: 2011
Abstract: Symptomatic induction of disc herniation involves both mechanical compression and chemical factors. Inhibitors of tumor necrosis factor-alpha (TNF-α) are known to reduce pain-related behavior in experimental models. Animals were divided into mechanical compression (MC) group; a stainless steel rod was inserted on the dorsal root ganglion, nucleus pulposus (NP) group: NP was harvested from the coccygeal vertebral disc, MC and NP group; rats were received stainless rod and NP, and sham group; rats were received neither rod nor NP. Rats in the MC group received a TNF-α antibody (10 mg/kg) (antibody group) or were not treatment (untreated group). The withdrawal thresholds of the MC, NP and MC+NP groups decreased significantly compared with the sham group. In the antibody group, the threshold was significantly higher than that of the untreated group. An anti-TNF-α antibody reduced allodynia caused by DRG compression.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/300
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/300/1/FksmJMedSci_57_p46.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.57.46
PubMed ID: 22353650
Other version: http://dx.doi.org/10.5387/fms.57.46
Rights: © 2011 The Fukushima Society of Medical Science
Appears in Collections:Vol.57 (2011)

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FksmJMedSci_57_p46.pdf517.63 kBAdobe PDFDownload

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