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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.57 (2011) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/300
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| Title: | A comparison of pain-related behavior following local application of nucleus pulposus and/or mechanical compression on the dorsal root ganglion |
| Other Titles: | Pain behavior of chemical or mechanical factors |
| Authors: | Sasaki, Nobuhisa
Sekiguchi, Miho
Shishido, Hiroaki
Kikuchi, Shin-ichi
Yabuki, Shoji
Konno, Shin-ichi |
| Affiliation: | 整形外科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 57 |
| Issue: | 2 |
| Start page: | 46 |
| End page: | 53 |
| Issue Date: | 2011 |
| Abstract: | Symptomatic induction of disc herniation involves both mechanical compression and chemical factors. Inhibitors of tumor necrosis factor-alpha (TNF-α) are known to reduce pain-related behavior in experimental models. Animals were divided into mechanical compression (MC) group; a stainless steel rod was inserted on the dorsal root ganglion, nucleus pulposus (NP) group: NP was harvested from the coccygeal vertebral disc, MC and NP group; rats were received stainless rod and NP, and sham group; rats were received neither rod nor NP. Rats in the MC group received a TNF-α antibody (10 mg/kg) (antibody group) or were not treatment (untreated group). The withdrawal thresholds of the MC, NP and MC+NP groups decreased significantly compared with the sham group. In the antibody group, the threshold was significantly higher than that of the untreated group. An anti-TNF-α antibody reduced allodynia caused by DRG compression. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/300 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/300/1/FksmJMedSci_57_p46.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.57.46 |
| PubMed ID: | 22353650 |
| Other version: | http://dx.doi.org/10.5387/fms.57.46 |
| Rights: | © 2011 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.57 (2011)
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