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Fukushima Journal of Medical Science >
Vol.57 (2011) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/299

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Title: A challenge to appropriate antibiotic use in children with respiratory infections: a 5-year single-institution experience
Other Titles: Treatment without antibiotics in children with cold
Authors: Matsumoto, Ayumi
Hashimoto, Koichi
Kawasaki, Yukihiko
Hosoya, Mitsuaki
Affiliation: 小児科学講座
Source title: Fukushima Journal of Medical Science
Volume: 57
Issue: 2
Start page: 33
End page: 45
Issue Date: 2011
Abstract: BACKGROUND: We have studied the rate of emergence of antibiotic-resistant Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae (H. influenzae) and the subsequent antibiotic use in host patients of those isolates at the Department of Pediatrics, Soma General Hospital, Fukushima. Moreover, we carried out several studies investigating the risks and benefits of antibiotic-free treatment for children with respiratory infections. In this report, we summarize our research and suggest better treatment options for pediatric patients with respiratory infections. METHODS: We investigated the necessity of antibiotic use in the treatment of pediatric inpatients with respiratory syncytial virus (RSV) infection, and tested our hypothesis that antibiotic-free treatment for common cold will reduce the number of resistant S. pneumoniae strains in the pediatric nasopharynx. Therefore, we restricted prescribing antibiotics for pediatric patients with respiratory infections. The rates of resistant S. pneumoniae and H. influenzae and the medication history of the host patients before and after the intervention were compared. RESULTS: We found that most of the RSV-infected patients recovered without antibiotic treatment, and that the antibiotic-free treatment inhibited the emergence of antibiotic-resistant strains. The rate of penicillin-resistant S. pneumoniae decreased but the rate of ampicillin-resistant H. influenzae did not change significantly during the study. CONCLUSION: We concluded that patients with respiratory infections can be treated without antibiotics, under careful examination and observation. Continued monitoring of such new interventions as well as recommending their use to other caregivers and physicians will help inhibit the spread of resistant strains.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/299
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/299/1/FksmJMedSci_57_p33.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.57.33
PubMed ID: 22353649
Other version: http://dx.doi.org/10.5387/fms.57.33
Rights: © 2011 The Fukushima Society of Medical Science
Appears in Collections:Vol.57 (2011)

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FksmJMedSci_57_p33.pdf440.97 kBAdobe PDFDownload

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