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Vol.57 (2011) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/280

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Title: Fluvastatin increases bone mineral density in postmenopausal women
Other Titles: Fluvastatin and bone mineral density
Authors: Gotoh, Mituhiro
Mizuno, Kenji
Ono, Yoshiaki
Takahashi, Michihiko
Affiliation: 基礎看護学部門 生態・機能学領域
Source title: Fukushima Journal of Medical Science
Volume: 57
Issue: 1
Start page: 19
End page: 27
Issue Date: 2011
Abstract: Although several studies have reported a lower risk of osteoporotic fracture in hypercholesterolemic patients (WHO IIa) treated with statin, longitudinal studies on the effects of statins on bone are lacking. The aim of the present study was to evaluate bone mineral density (BMD) and bone turnover changes induced by 3-year fluvastatin treatment in postmenopausal women. Twenty-eight consecutive postmenopausal non-diabetic, normotensive hypercholesterolemic women (64.0±3.6 years) were treated for 36 months with 30 mg/day fluvastatin and 28 non-diabetic, normotensive normocholesterolemic age- and body mass index-matched postmenopausal women served as the control subjects. The result revealed a significant increase of the BMD as compared with the level at the base line (p< 0.001) in the fluvastairn-treated group, from 6 months on ward after the start treatment. Significant differences of the BMD were found between the controls and fluvastatin-treated group (p< 0.001) were at 6, 12, 24 and 36 months after the start of the study. In conclusion our results, although obtained small sample of postmenopausal hypercholesterolemic women, suggest a probable favorable effect of fluvastatin on bone formation and BMD.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/280
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/280/1/FksmJMedSci_57_p19.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.57.19
PubMed ID: 21701079
Other version: http://dx.doi.org/10.5387/fms.57.19
Rights: © 2011 The Fukushima Society of Medical Science
Appears in Collections:Vol.57 (2011)

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