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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.57 (2011) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/280
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| タイトル: | Fluvastatin increases bone mineral density in postmenopausal women |
| その他のタイトル: | Fluvastatin and bone mineral density |
| 著者: | Gotoh, Mituhiro
Mizuno, Kenji
Ono, Yoshiaki
Takahashi, Michihiko |
| 学内所属: | 基礎看護学部門 生態・機能学領域 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 57 |
| 号: | 1 |
| 開始ページ: | 19 |
| 終了ページ: | 27 |
| 発行日: | 2011年 |
| 抄録: | Although several studies have reported a lower risk of osteoporotic fracture in hypercholesterolemic patients (WHO IIa) treated with statin, longitudinal studies on the effects of statins on bone are lacking. The aim of the present study was to evaluate bone mineral density (BMD) and bone turnover changes induced by 3-year fluvastatin treatment in postmenopausal women. Twenty-eight consecutive postmenopausal non-diabetic, normotensive hypercholesterolemic women (64.0±3.6 years) were treated for 36 months with 30 mg/day fluvastatin and 28 non-diabetic, normotensive normocholesterolemic age- and body mass index-matched postmenopausal women served as the control subjects. The result revealed a significant increase of the BMD as compared with the level at the base line (p< 0.001) in the fluvastairn-treated group, from 6 months on ward after the start treatment. Significant differences of the BMD were found between the controls and fluvastatin-treated group (p< 0.001) were at 6, 12, 24 and 36 months after the start of the study. In conclusion our results, although obtained small sample of postmenopausal hypercholesterolemic women, suggest a probable favorable effect of fluvastatin on bone formation and BMD. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/280 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/280/1/FksmJMedSci_57_p19.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.57.19 |
| PubMed番号: | 21701079 |
| 異版(出版者版等): | http://dx.doi.org/10.5387/fms.57.19 |
| 権利情報: | © 2011 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.57 (2011)
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