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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.57 (2011) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/279
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| Title: | Effect of methotrexate on fracture healing |
| Authors: | Satoh, Koichiro
Mark, Hans
Zachrisson, Peter
Rydevik, Björn
Byröd, Gunnar
Kikuchi, Shin-Ichi
Konno, Shin-Ichi
Sekiguchi, Miho |
| Affiliation: | 整形外科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 57 |
| Issue: | 1 |
| Start page: | 11 |
| End page: | 18 |
| Issue Date: | 2011 |
| Abstract: | Low doses of methotrexate (MTX) are safe and effective for treating adult and juvenile rheumatoid arthritis. However, because this powerful anti-inflammatory drug might negatively influence the healing of wounds and fractures, MTX administration is often stopped during surgical procedures. The present study assesses the effects of low- and high-dose MTX on early inflammatory processes and bone healing in an experimental model of fracture.Thirty male Sprague-Dawley rats were assigned to low- and high-dose MTX and control groups. A femur was cut using a reciprocating saw and a 2-mm fracture gap was made using a fixator. One or four weeks thereafter, macrophages were immunostained and new bone formation was histomorphometrically measured.Significantly less new bone was formed in the high-dose MTX, than in the control group (p< 0.01), whereas bone formation did not significantly differ between the low-dose MTX and control groups. These results suggested that a low dose of MTX does not affect the early process of endochondral bone formation during fracture healing, whereas a high dose might delay the progress of new periosteal bone formation. Although more macrophages were found in the groups treated with MTX, their impact on surrounding inflammatory processes remains unclear. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/279 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/279/1/FksmJMedSci_57_p11.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.57.11 |
| PubMed ID: | 21701078 |
| Other version: | http://dx.doi.org/10.5387/fms.57.11 |
| Rights: | © 2011 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.57 (2011)
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