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Vol.57 (2011) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/279

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Title: Effect of methotrexate on fracture healing
Authors: Satoh, Koichiro
Mark, Hans
Zachrisson, Peter
Rydevik, Björn
Byröd, Gunnar
Kikuchi, Shin-Ichi
Konno, Shin-Ichi
Sekiguchi, Miho
Affiliation: 整形外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 57
Issue: 1
Start page: 11
End page: 18
Issue Date: 2011
Abstract: Low doses of methotrexate (MTX) are safe and effective for treating adult and juvenile rheumatoid arthritis. However, because this powerful anti-inflammatory drug might negatively influence the healing of wounds and fractures, MTX administration is often stopped during surgical procedures. The present study assesses the effects of low- and high-dose MTX on early inflammatory processes and bone healing in an experimental model of fracture.Thirty male Sprague-Dawley rats were assigned to low- and high-dose MTX and control groups. A femur was cut using a reciprocating saw and a 2-mm fracture gap was made using a fixator. One or four weeks thereafter, macrophages were immunostained and new bone formation was histomorphometrically measured.Significantly less new bone was formed in the high-dose MTX, than in the control group (p< 0.01), whereas bone formation did not significantly differ between the low-dose MTX and control groups. These results suggested that a low dose of MTX does not affect the early process of endochondral bone formation during fracture healing, whereas a high dose might delay the progress of new periosteal bone formation. Although more macrophages were found in the groups treated with MTX, their impact on surrounding inflammatory processes remains unclear.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/279
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/279/1/FksmJMedSci_57_p11.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.57.11
PubMed ID: 21701078
Other version: http://dx.doi.org/10.5387/fms.57.11
Rights: © 2011 The Fukushima Society of Medical Science
Appears in Collections:Vol.57 (2011)

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FksmJMedSci_57_p11.pdf2.15 MBAdobe PDFDownload

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