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Vol.56 (2010) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/276

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Title: A 10-year-old girl with IgA nephropathy who 5 years later developed the characteristic features of henoch-schönlein purpura nephritis
Other Titles: A girl with IgAN and HSPN
Authors: Chishiki, Mina
Kawasaki, Yukihiko
Kaneko, Mariko
Ushijima, Yumiko
Ohara, Shinichiro
Abe, Yusaku
Suyama, Kazuhide
Hashimoto, Koichi
Hosoya, Mitsuaki
Affiliation: 小児科学講座
Source title: Fukushima Journal of Medical Science
Volume: 56
Issue: 2
Start page: 157
End page: 161
Issue Date: Dec-2010
Abstract: We report a patient who developed Henoch-Schönlein purpura (HSP) 5 years after she presented with immunoglobulin A nephropathy (IgAN). A 10-year-old Japanese female was identified with proteinuria and hematuria by a school urinary screening. The first renal biopsy showed mesangial proliferative glomerulonephritis with immunofluorescent findings consistent with IgAN. She was treated with prednisolone, warfarin, and dilazep dihydrochloride, and the proteinuria and hematuria disappeared 4 months after the onset of treatment. Five years later she developed abdominal pain, gross hematuria and a classic purpuric rash of HSP after acute pharyngitis. The second renal biopsy showed diffuse mesangial proliferation with cellular crescent formation, and the patient was treated with methylprednisolone pulse therapy, prednisolone and mizoribine, resulting in a gradual decrease in urinary protein excretion. Our patient is unusual in that she developed Henoch-Schönlein purpura nephritis 5 years after clinical and biopsy evidence of IgAN, which suggests that IgAN and HSP are different clinical manifestations of the same disease, probably sharing a common pathogenesis.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/276
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/276/1/FksmJMedSci_56_p157.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.56.157
PubMed ID: 21502718
Other version: http://dx.doi.org/10.5387/fms.56.157
Rights: © 2010 The Fukushima Society of Medical Science
Appears in Collections:Vol.56 (2010)

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