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Vol.56 (2010) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/275

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Title: A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation
Other Titles: Auto-PBSCT for renal amyloidosis
Authors: Ogawa, Kazuei
Ikeda, Kazuhiko
Furukawa, Miki
Harada-Shirado, Kayo
Mashimo, Yumiko
Takahashi, Hiroshi
Matsumoto, Hayato
Kimura, Satoshi
Shichishima-Nakamura, Akiko
Ohkawara, Hiroshi
Hashimoto, Yuko
Asahi, Koichi
Noji, Hideyoshi
Ohto, Hitoshi
Takeishi, Yasuchika
Affiliation: 循環器・血液内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 56
Issue: 2
Start page: 151
End page: 156
Issue Date: Dec-2010
Abstract: Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema. We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing high-dose chemotherapy followed by autologous peripheral blood stem-cell transplantation (auto-PBSCT). The patient was a man aged in his 50s who had developed nephrotic syndrome. Bone marrow aspiration and kidney biopsy determined that the cause of the nephrotic syndrome was renal amyloidosis due to multiple myeloma, and the patient was admitted to our department in July 2003. After one course of chemotherapy, auto-PBSCT was performed in March 2004. Following transplantation, serum M-protein was no longer detectable from March 2005, and the patient achieved complete hematological remission. Subsequently, proteinuria decreased, serum albumin levels normalized, and nephrotic syndrome improved. As of 6 years after transplantation, in March 2010, the patient remained in remission, meaning that auto-PBSCT proved extremely effective as a treatment for renal amyloidosis in this case.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/275
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/275/1/FksmJMedSci_56_p151.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.56.151
PubMed ID: 21502717
Other version: http://dx.doi.org/10.5387/fms.56.151
Rights: © 2010 The Fukushima Society of Medical Science
Appears in Collections:Vol.56 (2010)

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FksmJMedSci_56_p151.pdf818.37 kBAdobe PDFDownload

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