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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.56 (2010) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/269
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| Title: | Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome |
| Other Titles: | Endothelial function in SAS |
| Authors: | Yoshihisa, Akiomi
Owada, Takashi
Hoshino, Yasuto
Miyata, Makiko
Misaka, Tomofumi
Sato, Takamasa
Suzuki, Satoshi
Sakamoto, Nobuo
Sugimoto, Koichi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-Ichi
Ishibashi, Toshiyuki
Takeishi, Yasuchika |
| Affiliation: | 循環器・血液内科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 56 |
| Issue: | 2 |
| Start page: | 115 |
| End page: | 120 |
| Issue Date: | Dec-2010 |
| Abstract: | [Background] Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient. [Methods] Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36). [Results] There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01). [Conclusions] Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/269 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/269/1/FksmJMedSci_56_p115.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.56.115 |
| PubMed ID: | 21502711 |
| Other version: | http://dx.doi.org/10.5387/fms.56.115 |
| Rights: | © 2010 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.56 (2010)
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