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Vol.56 (2010) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/269

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Title: Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome
Other Titles: Endothelial function in SAS
Authors: Yoshihisa, Akiomi
Owada, Takashi
Hoshino, Yasuto
Miyata, Makiko
Misaka, Tomofumi
Sato, Takamasa
Suzuki, Satoshi
Sakamoto, Nobuo
Sugimoto, Koichi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-Ichi
Ishibashi, Toshiyuki
Takeishi, Yasuchika
Affiliation: 循環器・血液内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 56
Issue: 2
Start page: 115
End page: 120
Issue Date: Dec-2010
Abstract: [Background] Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient. [Methods] Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36). [Results] There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01). [Conclusions] Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/269
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/269/1/FksmJMedSci_56_p115.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.56.115
PubMed ID: 21502711
Other version: http://dx.doi.org/10.5387/fms.56.115
Rights: © 2010 The Fukushima Society of Medical Science
Appears in Collections:Vol.56 (2010)

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