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Vol.56 (2010) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/258

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Title: Non-antibiotic treatment for pediatric outpatients with common cold inhibits the emergence of drug resistant pneumococci
Other Titles: Medicine without antibiotics to children with cold
Authors: Matsumoto, Ayumi
Takeyama, Aya
Hashimoto, Koichi
Ito, Masaki
Katayose, Masahiko
Kato, Kazuo
Kawasaki, Yukihiko
Hosoya, Mitsuaki
Affiliation: 小児科学講座
Source title: Fukushima Journal of Medical Science
Volume: 56
Issue: 1
Start page: 28
End page: 37
Issue Date: Jun-2010
Abstract: The occurrence of drug resistant Streptococcus pneurmoniae (S. pneumoniae) is very high in Japan. Unnecessary use of antibiotics had been thought to cause this problem but previous studies had not clearly showed that the decreasing rate of antibiotic use had been related to the reduction of the prevalence of resistant strains. In this study, we tried to prove that non-antibiotic treatment for common cold would reduce the antibiotic resistant S. pneumoniae in nasopharynx in children. Forty-five children with the common cold were randomly selected from pediatric patients who had taken antibiotics within the past three months. We collected nasopharyngeal swabs from all of the participants and once again after a period of 2 to 3 months without using any antibiotics. Twenty-four of these patients had the S. pneumoniae strains isolated. Then these strains were undergone a susceptibility test and drug-resistant gene detection. The susceptibility test reveled that patients with penicillin-resistant strains decreased from 17 to 7 (p < 0.01). The test also reveled that the decreased number of patients had strains that were resistant to cefditren. The gene detection revealed that none of the patients acquired a higher resistance to penicillin. Our study suggests that the treatment without antibiotics reduces the drug-resistant S. pneumoniae. Controlled antibiotic use in children might prevent children from carrying the antibiotic resistant S. pneumoniae.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/258
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/258/1/FksmJMedSci_56_p28.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.56.28
PubMed ID: 21485653
Other version: http://dx.doi.org/10.5387/fms.56.28
Rights: © 2010 The Fukushima Society of Medical Science
Appears in Collections:Vol.56 (2010)

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