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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.55 (2009) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/240
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| Title: | RETRACTED: Reversal of vecuronium with neostigmine: a comparison between male and female patients |
| Other Titles: | Gender and reversal effect of neostigmine |
| Authors: | Saitoh, Yuhji
Aoki, Kenichi
Okazaki, Michiya
Hirama, Takahiro
Isosu, Tsuyoshi
Murakawa, Masahiro |
| Affiliation: | 麻酔科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 55 |
| Issue: | 2 |
| Start page: | 61 |
| End page: | 70 |
| Issue Date: | Dec-2009 |
| Abstract: | We investigated the differences between males and females in the reversal effect of neostigmine on neuromuscular blockade. Thirty male and 30 female patients undergoing elective general anesthesia were studied. Vecuronium was given in all patients anesthetized with nitrous oxide, oxygen, and sevoflurane. After the surgical procedure, when T1 (1st response in train-of-four (TOF))/control returned to 0.25, neostigmine 40 microg/kg in combination with atropine 20 microg/kg was given to antagonize residual neuromuscular blockade. Three, six, nine, 12, and 15 minutes after neostigmine reversal, T1/control or TOF ratio (T4/T1) did not significantly differ between the sexes. Also, 15 minutes after neostigmine administration, the number of patients in whom recovery from neuromuscular blockade was sufficient to guarantee good respiratory function, i.e., TOF ratio > 0.74, did not significantly differ between the sexes. In contrast, 15 minutes after neostigmine, the number of patients in whom recovery from neuromuscular blockade was adequate to ensure satisfactory recovery from neuromuscular blockade including the return of the faculty of sight, i.e., TOF ratio > 0.9, was significantly less in the males than in females (6 vs. 14, P = 0.028). In conclusion, 15 min after neostigmine, TOF ratio less often returns to a value of more than 0.9 in males than in females. |
| Description: | This article has been retracted. Retraction notice: Fukushima Journal of Medical Science. 2019; 65(1):24. 撤回論文 |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/240 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/240/3/FksmJMedSci_55_p61_RETRACTED.pdf |
| ISSN: | 0016-2590 |
| PubMed ID: | 20608096 |
| Rights: | © 2009 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.55 (2009)
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