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Vol.55 (2009) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/240

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Title: RETRACTED: Reversal of vecuronium with neostigmine: a comparison between male and female patients
Other Titles: Gender and reversal effect of neostigmine
Authors: Saitoh, Yuhji
Aoki, Kenichi
Okazaki, Michiya
Hirama, Takahiro
Isosu, Tsuyoshi
Murakawa, Masahiro
Affiliation: 麻酔科学講座
Source title: Fukushima Journal of Medical Science
Volume: 55
Issue: 2
Start page: 61
End page: 70
Issue Date: Dec-2009
Abstract: We investigated the differences between males and females in the reversal effect of neostigmine on neuromuscular blockade. Thirty male and 30 female patients undergoing elective general anesthesia were studied. Vecuronium was given in all patients anesthetized with nitrous oxide, oxygen, and sevoflurane. After the surgical procedure, when T1 (1st response in train-of-four (TOF))/control returned to 0.25, neostigmine 40 microg/kg in combination with atropine 20 microg/kg was given to antagonize residual neuromuscular blockade. Three, six, nine, 12, and 15 minutes after neostigmine reversal, T1/control or TOF ratio (T4/T1) did not significantly differ between the sexes. Also, 15 minutes after neostigmine administration, the number of patients in whom recovery from neuromuscular blockade was sufficient to guarantee good respiratory function, i.e., TOF ratio > 0.74, did not significantly differ between the sexes. In contrast, 15 minutes after neostigmine, the number of patients in whom recovery from neuromuscular blockade was adequate to ensure satisfactory recovery from neuromuscular blockade including the return of the faculty of sight, i.e., TOF ratio > 0.9, was significantly less in the males than in females (6 vs. 14, P = 0.028). In conclusion, 15 min after neostigmine, TOF ratio less often returns to a value of more than 0.9 in males than in females.
Description: This article has been retracted. Retraction notice: Fukushima Journal of Medical Science. 2019; 65(1):24. 撤回論文
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/240
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/240/3/FksmJMedSci_55_p61_RETRACTED.pdf
ISSN: 0016-2590
PubMed ID: 20608096
Rights: © 2009 The Fukushima Society of Medical Science
Appears in Collections:Vol.55 (2009)

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FksmJMedSci_55_p61_RETRACTED.pdf951.89 kBAdobe PDFDownload

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