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福島医学会 = The Fukushima Society of Medical Science >
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Vol.55 (2009) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/238

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Title: Bilirubin and its oxidative metabolite biopyrrins in patients with acute myocardial infarction
Other Titles: Bilirubin and biopyrrins in myocardial infarction
Authors: Kunii, Hiroyuki
Ishikawa, Kazunobu
Yamaguchi, Tokio
Komatsu, Nobuo
Ichihara, Toshikatsu
Maruyama, Yukio
Affiliation: 内科学第一講座
医療人育成・支援センター
Source title: Fukushima Journal of Medical Science
Volume: 55
Issue: 2
Start page: 39
End page: 51
Issue Date: Dec-2009
Abstract: This study aimed to assess the involvement of bilirubin and its oxidative metabolite biopyrrin in patients with acute myocardial infarction (AMI) and to determine the responsible organs that overproduce these molecules. One hundred thirteen consecutive patients hospitalized for AMI were analyzed. Levels of serum bilirubin, plasma and urinary biopyrrins were measured on the day of admission, day 2, 3, 7 and 14. Expressions of biopyrrins and heme oxygenase-1 (HO-1), a stress-responsive bilirubin-producing enzyme, in heart, aorta, kidney, liver and lung were immunostained with autopsied specimens. Serum bilirubin, plasma and urinary biopyrrins were increased within 24 hr, formed a peak on day 3 and then decreased by day 14. These three parameters were well correlated to each other. The maximum biopyrrin elevation was higher in death cases and associated with impaired left ventricular function. Immunohistochemical analyses revealed biopyrrin accumulation and HO-1 expression in the infracted myocardium. Immunoreactive HO-1 and biopyrrins were also observed in renal tubular cells, aortic wall and lung. Serum bilirubin and its metabolite biopyrrins were elevated in patients with AMI. Plasma and urinary biopyrrin elevation were associated with mortality and morbidity. Induction of anti-oxidative enzyme HO-1 seemed to be involved in the activation of bilirubin/biopyrrin pathway.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/238
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/238/1/FksmJMedSci_55_p39.pdf
ISSN: 0016-2590
PubMed ID: 20608094
Rights: © 2009 The Fukushima Society of Medical Science
Appears in Collections:Vol.55 (2009)

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