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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.55 (2009) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/238
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| タイトル: | Bilirubin and its oxidative metabolite biopyrrins in patients with acute myocardial infarction |
| その他のタイトル: | Bilirubin and biopyrrins in myocardial infarction |
| 著者: | Kunii, Hiroyuki
Ishikawa, Kazunobu
Yamaguchi, Tokio
Komatsu, Nobuo
Ichihara, Toshikatsu
Maruyama, Yukio |
| 学内所属: | 内科学第一講座
医療人育成・支援センター |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 55 |
| 号: | 2 |
| 開始ページ: | 39 |
| 終了ページ: | 51 |
| 発行日: | 2009年12月 |
| 抄録: | This study aimed to assess the involvement of bilirubin and its oxidative metabolite biopyrrin in patients with acute myocardial infarction (AMI) and to determine the responsible organs that overproduce these molecules. One hundred thirteen consecutive patients hospitalized for AMI were analyzed. Levels of serum bilirubin, plasma and urinary biopyrrins were measured on the day of admission, day 2, 3, 7 and 14. Expressions of biopyrrins and heme oxygenase-1 (HO-1), a stress-responsive bilirubin-producing enzyme, in heart, aorta, kidney, liver and lung were immunostained with autopsied specimens. Serum bilirubin, plasma and urinary biopyrrins were increased within 24 hr, formed a peak on day 3 and then decreased by day 14. These three parameters were well correlated to each other. The maximum biopyrrin elevation was higher in death cases and associated with impaired left ventricular function. Immunohistochemical analyses revealed biopyrrin accumulation and HO-1 expression in the infracted myocardium. Immunoreactive HO-1 and biopyrrins were also observed in renal tubular cells, aortic wall and lung. Serum bilirubin and its metabolite biopyrrins were elevated in patients with AMI. Plasma and urinary biopyrrin elevation were associated with mortality and morbidity. Induction of anti-oxidative enzyme HO-1 seemed to be involved in the activation of bilirubin/biopyrrin pathway. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/238 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/238/1/FksmJMedSci_55_p39.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.55.39 |
| PubMed番号: | 20608094 |
| 関連ページ: | https://doi.org/10.5387/fms.55.39 |
| 権利情報: | © 2009 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.55 (2009)
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