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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.55 (2009) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/232
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| Title: | Role for netrin-1 in sensory axonal guidance in higher vertebrates |
| Other Titles: | Role for netrin-1 in sensory axonal guidance |
| Authors: | Masuda, Tomoyuki
Sakuma, Chie
Yaginuma, Hiroyuki |
| Affiliation: | 神経解剖・発生学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 55 |
| Issue: | 1 |
| Start page: | 1 |
| End page: | 6 |
| Issue Date: | Jun-2009 |
| Abstract: | During development, dorsal root ganglion (DRG) neurons in higher vertebrates extend their axons centrally to the spinal cord through the dorsal root entry zone (DREZ) and peripherally to muscle and skin targets. After entering the spinal cord, DRG axons project into the dorsal mantle layer. In this review, we focus on evidence showing the role for netrin-1 in forming sensory axonal trajectories. Netrin-1 is a diffusible axonal guidance molecule that chemorepels developing DRG axons. When DRG axons project toward the DREZ, ventral spinal cord-derived netrin-1 prevents DRG axons from projecting aberrantly toward the ventral spinal cord. At later stages, the dorsal spinal cord cells transiently express netrin-1. This dorsal spinal cord-derived netrin-1 prevents DRG axons from invading the dorsal spinal cord during the waiting period. Together, the data reviewed provide strong evidence that netrin-1 plays a crucial role in sensory axon projection during development. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/232 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/232/1/FksmJMedSci_55_p1.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.55.1 |
| PubMed ID: | 19999164 |
| Related Page: | https://doi.org/10.5387/fms.55.1 |
| Rights: | © 2009 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.55 (2009)
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