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Vol.55 (2009) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/232

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Title: Role for netrin-1 in sensory axonal guidance in higher vertebrates
Other Titles: Role for netrin-1 in sensory axonal guidance
Authors: Masuda, Tomoyuki
Sakuma, Chie
Yaginuma, Hiroyuki
Affiliation: 神経解剖・発生学講座
Source title: Fukushima Journal of Medical Science
Volume: 55
Issue: 1
Start page: 1
End page: 6
Issue Date: Jun-2009
Abstract: During development, dorsal root ganglion (DRG) neurons in higher vertebrates extend their axons centrally to the spinal cord through the dorsal root entry zone (DREZ) and peripherally to muscle and skin targets. After entering the spinal cord, DRG axons project into the dorsal mantle layer. In this review, we focus on evidence showing the role for netrin-1 in forming sensory axonal trajectories. Netrin-1 is a diffusible axonal guidance molecule that chemorepels developing DRG axons. When DRG axons project toward the DREZ, ventral spinal cord-derived netrin-1 prevents DRG axons from projecting aberrantly toward the ventral spinal cord. At later stages, the dorsal spinal cord cells transiently express netrin-1. This dorsal spinal cord-derived netrin-1 prevents DRG axons from invading the dorsal spinal cord during the waiting period. Together, the data reviewed provide strong evidence that netrin-1 plays a crucial role in sensory axon projection during development.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/232
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/232/1/FksmJMedSci_55_p1.pdf
ISSN: 0016-2590
PubMed ID: 19999164
Rights: © 2009 The Fukushima Society of Medical Science
Appears in Collections:Vol.55 (2009)

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FksmJMedSci_55_p1.pdf1.07 MBAdobe PDFDownload

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