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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.55 (2009) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/232
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| タイトル: | Role for netrin-1 in sensory axonal guidance in higher vertebrates |
| その他のタイトル: | Role for netrin-1 in sensory axonal guidance |
| 著者: | Masuda, Tomoyuki
Sakuma, Chie
Yaginuma, Hiroyuki |
| 学内所属: | 神経解剖・発生学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 55 |
| 号: | 1 |
| 開始ページ: | 1 |
| 終了ページ: | 6 |
| 発行日: | 2009年6月 |
| 抄録: | During development, dorsal root ganglion (DRG) neurons in higher vertebrates extend their axons centrally to the spinal cord through the dorsal root entry zone (DREZ) and peripherally to muscle and skin targets. After entering the spinal cord, DRG axons project into the dorsal mantle layer. In this review, we focus on evidence showing the role for netrin-1 in forming sensory axonal trajectories. Netrin-1 is a diffusible axonal guidance molecule that chemorepels developing DRG axons. When DRG axons project toward the DREZ, ventral spinal cord-derived netrin-1 prevents DRG axons from projecting aberrantly toward the ventral spinal cord. At later stages, the dorsal spinal cord cells transiently express netrin-1. This dorsal spinal cord-derived netrin-1 prevents DRG axons from invading the dorsal spinal cord during the waiting period. Together, the data reviewed provide strong evidence that netrin-1 plays a crucial role in sensory axon projection during development. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/232 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/232/1/FksmJMedSci_55_p1.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.55.1 |
| PubMed番号: | 19999164 |
| 関連ページ: | https://doi.org/10.5387/fms.55.1 |
| 権利情報: | © 2009 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.55 (2009)
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