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福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.54 (2008) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/226

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Title: The pathogenesis and treatment of IgA nephropathy
Other Titles: The pathogenesis and treatment of CGN
Authors: Kawasaki, Yukihiko
Affiliation: 小児科学講座
Source title: Fukushima Journal of Medical Science
Volume: 54
Issue: 2
Start page: 43
End page: 60
Issue Date: Dec-2008
Abstract: IgA nephropathy (IgAN) is one of the most common causes of glomerulonephritis in the world. The proliferative and crescentic forms of IgA are found in up to 30% of cases and are associated with nephritic-range proteinuria, accelerated hypertension, and accelerated decline toward ESRD. Thus, it is important to investigate the mechanism of the onset of IgAN and to identify the most appropriate treatment. We herein review the pathogenesis and treatment of IgA nephropathy. As to the pathogenesis, we found that CB4 provoked exacerbation of renal pathologic findings in HIGA mice via endothelial injury, IFN-gamma production, and dysfunction of the mesangial pathway and could possibly become one of the factors involved in the mechanism of the onset or evolution of human IgAN. As to the treatment of IgAN, we evaluated the efficacy of tonsillectomy plus prednisolone, warfarin, and dipyridamole including methylprednisolone pulse therapy (tonsillectomy plus pulse therapy) and prednisolone, warfarin, and dipyridamole including mizoribine (PWDM) for the treatment of diffuse IgAN in children. These therapies were effective in ameliorating the proteinuria and histological severity of patients with IgAN. Furthermore the detail investigations into the pathogenesis of IgAN and double-blind randomized control studies on children with IgAN will be necessary.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/226
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/226/1/FksmJMedSci_54_p43.pdf
ISSN: 0016-2590
PubMed ID: 19418967
Rights: © 2008 The Fukushima Society of Medical Science
Appears in Collections:Vol.54 (2008)

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FksmJMedSci_54_p43.pdf2.84 MBAdobe PDFDownload

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