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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.54 (2008) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/226
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| タイトル: | The pathogenesis and treatment of IgA nephropathy |
| その他のタイトル: | The pathogenesis and treatment of CGN |
| 著者: | Kawasaki, Yukihiko |
| 学内所属: | 小児科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 54 |
| 号: | 2 |
| 開始ページ: | 43 |
| 終了ページ: | 60 |
| 発行日: | 2008年12月 |
| 抄録: | IgA nephropathy (IgAN) is one of the most common causes of glomerulonephritis in the world. The proliferative and crescentic forms of IgA are found in up to 30% of cases and are associated with nephritic-range proteinuria, accelerated hypertension, and accelerated decline toward ESRD. Thus, it is important to investigate the mechanism of the onset of IgAN and to identify the most appropriate treatment. We herein review the pathogenesis and treatment of IgA nephropathy. As to the pathogenesis, we found that CB4 provoked exacerbation of renal pathologic findings in HIGA mice via endothelial injury, IFN-gamma production, and dysfunction of the mesangial pathway and could possibly become one of the factors involved in the mechanism of the onset or evolution of human IgAN. As to the treatment of IgAN, we evaluated the efficacy of tonsillectomy plus prednisolone, warfarin, and dipyridamole including methylprednisolone pulse therapy (tonsillectomy plus pulse therapy) and prednisolone, warfarin, and dipyridamole including mizoribine (PWDM) for the treatment of diffuse IgAN in children. These therapies were effective in ameliorating the proteinuria and histological severity of patients with IgAN. Furthermore the detail investigations into the pathogenesis of IgAN and double-blind randomized control studies on children with IgAN will be necessary. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/226 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/226/1/FksmJMedSci_54_p43.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.54.43 |
| PubMed番号: | 19418967 |
| 関連ページ: | https://doi.org/10.5387/fms.54.43 |
| 権利情報: | © 2008 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.54 (2008)
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