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Vol.70 (2024) >

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Title: Roles of extracellular matrix in lung diseases
Authors: Tanino, Yoshinori
Affiliation: 呼吸器内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 70
Issue: 1
Start page: 1
End page: 9
Issue Date: 2024
Abstract: Extracellular matrix (ECM) is a non-cellular constituent found in all tissues and organs. Although ECM was previously recognized as a mere "molecular glue" that supports the tissue structure of organs such as the lungs, it has recently been reported that ECM has important biological activities for tissue morphogenesis, inflammation, wound healing, and tumor progression. Proteoglycans are the main constituent of ECM, with growing evidence that proteoglycans and their associated glycosaminoglycans play important roles in the pathogenesis of several diseases. However, their roles in the lungs are incompletely understood. Leukocyte migration into the lung is one of the main aspects involved in the pathogenesis of several lung diseases. Glycosaminoglycans bind to chemokines and their interaction fine-tunes leukocyte migration into the affected organs. This review focuses on the role chemokine and glycosaminoglycan interactions in neutrophil migration into the lung. Furthermore, this review presents the role of proteoglycans such as syndecan, versican, and hyaluronan in inflammatory and fibrotic lung diseases.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/2208
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/2208/1/FksmJMedSci_70_p1.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2023-07
PubMed ID: 38267030
Related Page: https://doi.org/10.5387/fms.2023-07
Rights: © 2024 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.70 (2024)

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FksmJMedSci_70_p1.pdf1.35 MBAdobe PDFDownload

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