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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.69 (2023) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/2197
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| タイトル: | Harnessing allogeneic CD4+ T cells to reinvigorate host endogenous antitumor immunity |
| 著者: | Mochizuki, Kazuhiro |
| 学内所属: | 小児腫瘍内科 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 69 |
| 号: | 3 |
| 開始ページ: | 157 |
| 終了ページ: | 165 |
| 発行日: | 2023年 |
| 抄録: | Immune checkpoint blockade (ICB) therapies developed over the past decade have been among the most promising approaches for the treatment of patients with advanced cancers. However, the overall objective response rate of ICB therapy for various cancers remains insufficient. Hence, novel strategies are required to improve the efficacy of immunotherapy for advanced cancers. The graft-versus-tumor (GVT) effect, which reflects strong antitumor immunity, is known to occur after allogeneic hematopoietic stem cell transplantation (HSCT). The GVT effect is mainly caused by transplanted donor lymphocytes that recognize and react to distinct alloantigens on tumor cells. In contrast, transplanted allogeneic cells can, in some instances, induce endogenous antitumor immunity in recipients if the graft has been rejected. Because of this ability, allogeneic cells have also been used to induce endogenous antitumor immunity without HSCT, and their beneficial immune response is referred to as the "allogenic effect." Here, we review the usefulness of allogeneic cells, particularly allogeneic CD4+ T cells, in cancer immunotherapy by highlighting their unique potential to induce host endogenous antitumor immunity. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/2197 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/2197/1/FksmJMedSci_69_p157.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.23-00001 |
| PubMed番号: | 37880140 |
| 関連ページ: | https://doi.org/10.5387/fms.23-00001 |
| 権利情報: | © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 権利情報: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 出現コレクション: | Vol.69 (2023)
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