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福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.69 (2023) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/2197

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Title: Harnessing allogeneic CD4+ T cells to reinvigorate host endogenous antitumor immunity
Authors: Mochizuki, Kazuhiro
Affiliation: 小児腫瘍内科
Source title: Fukushima Journal of Medical Science
Volume: 69
Issue: 3
Start page: 157
End page: 165
Issue Date: 2023
Abstract: Immune checkpoint blockade (ICB) therapies developed over the past decade have been among the most promising approaches for the treatment of patients with advanced cancers. However, the overall objective response rate of ICB therapy for various cancers remains insufficient. Hence, novel strategies are required to improve the efficacy of immunotherapy for advanced cancers. The graft-versus-tumor (GVT) effect, which reflects strong antitumor immunity, is known to occur after allogeneic hematopoietic stem cell transplantation (HSCT). The GVT effect is mainly caused by transplanted donor lymphocytes that recognize and react to distinct alloantigens on tumor cells. In contrast, transplanted allogeneic cells can, in some instances, induce endogenous antitumor immunity in recipients if the graft has been rejected. Because of this ability, allogeneic cells have also been used to induce endogenous antitumor immunity without HSCT, and their beneficial immune response is referred to as the "allogenic effect." Here, we review the usefulness of allogeneic cells, particularly allogeneic CD4+ T cells, in cancer immunotherapy by highlighting their unique potential to induce host endogenous antitumor immunity.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/2197
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/2197/1/FksmJMedSci_69_p157.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.23-00001
PubMed ID: 37880140
Related Page: https://doi.org/10.5387/fms.23-00001
Rights: © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.69 (2023)

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FksmJMedSci_69_p157.pdf538.59 kBAdobe PDFDownload

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