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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.69 (2023) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/2159
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| Title: | Differences in response to treatment in children with severe IgA nephropathy according to patient age |
| Authors: | Kawasaki, Yukihiko
Kume, Yohei
Ono, Atsushi
Maeda, Ryo
Go, Hayato |
| Affiliation: | 地域医療支援センター
小児科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 69 |
| Issue: | 2 |
| Start page: | 125 |
| End page: | 132 |
| Issue Date: | 2023 |
| Abstract: | Aim: To clarify whether the response to treatment of IgA nephropathy (IgAN) differs depending on patient age, we examined the response to treatment according to age of onset in children with IgAN. Methods: We collected data for 44 children with severe IgAN. The children were retrospectively divided into three groups based on their age at disease onset. Group 1 consisted of 24 children under 11 years old, group 2 consisted of 9 children aged 12 to 13 years, and group 3 consisted of 11 children aged over 14 years old. The clinical features and prognosis were analyzed for each group. Results: The urinary protein excretion and serum IgA values in group 3 were higher than those in groups 1 and 2 at the most recent follow up, and histological findings showed that the MESTCG scores in group 3 were higher than those in group 1. Furthermore, the incidence of patients with persistent nephropathy or renal insufficiency in group 3 was higher than those in groups 1 and 2. Conclusions: Patients aged 14 years and older with IgAN may respond poorly to treatment compared with those younger than 14 years old. Therefore, care must be taken regarding response to treatment and relapse when treating older children. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/2159 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/2159/1/FksmJMedSci_69_p125.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2022-42 |
| PubMed ID: | 37164762 |
| Related Page: | https://doi.org/10.5387/fms.2022-42 |
| Rights: | © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.69 (2023)
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