DSpace Fukushima Medical University

福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.69 (2023) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/2155

Files in This Item:

File Description SizeFormat
FksmJMedSci_69_p85.pdf618.69 kBAdobe PDFDownload
Title: Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease
Authors: Matsuda, Hiroshi
Yamao, Tensho
Affiliation: 生体機能イメージング講座
Source title: Fukushima Journal of Medical Science
Volume: 69
Issue: 2
Start page: 85
End page: 93
Issue Date: 2023
Abstract: Alzheimer's disease (AD) is diagnosed by the presence of both amyloid β and tau proteins. Recent advances in molecular PET imaging have made it possible to assess the accumulation of these proteins in the living brain. PET ligands have been developed that bind to 3R/4R tau in AD, but not to 3R tau or 4R tau alone. Of the first-generation PET ligands, 18F-flortaucipir has recently been approved by the Food and Drug Administration. Several second-generation PET probes with less off-target binding have been developed and are being applied clinically. Visual interpretation of tau PET should be based on neuropathological neurofibrillary tangle staging instead of a simple positive or negative classification. Four visual read classifications have been proposed: "no uptake," "medial temporal lobe (MTL) only," "MTL AND," and "outside MTL." As an adjunct to visual interpretation, quantitative analysis has been proposed using MRI-based native space FreeSurfer parcellations. The standardized uptake value ratio of the target area is measured using the cerebellar gray matter as a reference region. In the near future, the Centiloid scale of tau PET is expected to be used as a harmonized value for standardizing each analytical method or PET ligand used, similar to amyloid PET.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/2155
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/2155/1/FksmJMedSci_69_p85.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2023-08
PubMed ID: 37302841
Related Page: https://doi.org/10.5387/fms.2023-08
Rights: © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.69 (2023)

Files in This Item:

File Description SizeFormat
FksmJMedSci_69_p85.pdf618.69 kBAdobe PDFDownload

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard