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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.69 (2023) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/2155
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| Title: | Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease |
| Authors: | Matsuda, Hiroshi
Yamao, Tensho |
| Affiliation: | 生体機能イメージング講座
診療放射線科学科 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 69 |
| Issue: | 2 |
| Start page: | 85 |
| End page: | 93 |
| Issue Date: | 2023 |
| Abstract: | Alzheimer's disease (AD) is diagnosed by the presence of both amyloid β and tau proteins. Recent advances in molecular PET imaging have made it possible to assess the accumulation of these proteins in the living brain. PET ligands have been developed that bind to 3R/4R tau in AD, but not to 3R tau or 4R tau alone. Of the first-generation PET ligands, 18F-flortaucipir has recently been approved by the Food and Drug Administration. Several second-generation PET probes with less off-target binding have been developed and are being applied clinically. Visual interpretation of tau PET should be based on neuropathological neurofibrillary tangle staging instead of a simple positive or negative classification. Four visual read classifications have been proposed: "no uptake," "medial temporal lobe (MTL) only," "MTL AND," and "outside MTL." As an adjunct to visual interpretation, quantitative analysis has been proposed using MRI-based native space FreeSurfer parcellations. The standardized uptake value ratio of the target area is measured using the cerebellar gray matter as a reference region. In the near future, the Centiloid scale of tau PET is expected to be used as a harmonized value for standardizing each analytical method or PET ligand used, similar to amyloid PET. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/2155 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/2155/1/FksmJMedSci_69_p85.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2023-08 |
| PubMed ID: | 37302841 |
| Related Page: | https://doi.org/10.5387/fms.2023-08 |
| Rights: | © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.69 (2023)
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