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Vol.53 (2007) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/212

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Title: Inhibitory oligodeoxynucleotide improves glomerulonephritis and prolongs survival in MRL-lpr/lpr mice
Other Titles: Inhibitory ODN ameliorates autoimmune nephritis
Authors: Hoshi, Namiko
Watanabe, Hiroshi
Kobayashi, Hiroko
Sekine, Hideharu
Hoshi, Nobuo
Sugino, Takashi
Suzuki, Toshimitsu
Sato, Yukio
Ohira, Hiromasa
Affiliation: 内科学第二講座
病理学第二講座
大学健康管理センター
Source title: Fukushima Journal of Medical Science
Volume: 53
Issue: 2
Start page: 70
End page: 84
Issue Date: Dec-2007
Abstract: Inhibitory oligodeoxynucleotides (ODNs), which are capable of blocking CpG-induced inflammation, have been anticipated to be beneficial therapeutic agents for autoimmune diseases. In this study, we show that GpC ODN, which inverted the cytosine guanine sequence of CpG motif to guanine cytosine sequence, is an inhibitory ODN. The inhibitory effects of GpC ODN on CpG ODN-induced immune activation were confirmed by cytokine assay using splenocytes from lupus-prone MRL-lpr/lpr mice. In vivo, injecting MRL-lpr/lpr mice with GpC ODN did not reduce the deposition of IgG and C3 in the glomeruli, the serum level of IL-12, the serum level of rheumatoid factors and anti-ds DNA antibody, or alter the composition of IgG isotypes of anti-ds DNA antibody. However, the mice in the GpC group showed less proteinuria, significantly lower blood urea nitrogen levels (BUN) and significantly prolonged survival. Our results suggest that inhibitory ODNs, such as GpC ODN, have the potential to become a treatment for autoimmune diseases, like lupus nephritis.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/212
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/212/1/FksmJMedSci_53_p70.pdf
ISSN: 0016-2590
PubMed ID: 18402287
Rights: © 2007 The Fukushima Society of Medical Science
Appears in Collections:Vol.53 (2007)

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