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Vol.53 (2007) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/206

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Title: Keishikajutsubuto (Guizhi-shu-fu-tang) treatment for refractory accumulation of synovial fluid in a patient with pustulotic arthro-osteitis
Other Titles: Keishikajutsubuto for accumulation of synovial fluid
Authors: Satoh, Koichiro
Takano, Shizuko
Kobayashi, Toshio
Affiliation: 附属リハビリテーション研究所
薬理学講座
Source title: Fukushima Journal of Medical Science
Volume: 53
Issue: 1
Start page: 33
End page: 38
Issue Date: Jun-2007
Abstract: We present a patient, a sixty-seven-year-old woman, who had refractory accumulation of synovial fluid in the knee joints with pustulotic arthro-osteitis for more than 10 years. Fifty ml of synovial fluid from her right knee contained 6,480 pg/ml of interleukin-8 (IL-8) and 15,000/mm3 of neutorophils. At first, she was treated with 400 mg/day of indomethacin farnesil (a prodrug that is converted to indomethacin after intestinal absorption) for 24 weeks. Although, the volume of synovial fluid in her right knee had decreased to 35 ml at the 16th week, it increased to 50 ml at the 24th week again. She was treated with Kampo medicine, Keishikajutsubuto (Guizhi-shu-fu-tang). In the present case, Keishikajutsubuto showed more therapeutic effect to pustulotic arthro-osteitis to reduce volume of synovial fluid to almost 0 ml, IL-8 concentration to 673 pg/ml and number of neutrophils to 660/mm3. Our data showed that Keishikajutsubuto might be suitable for this patient to regulate synovial fluid volume, reduce IL-8 concentration in synovial fluid, and block neutrophils migration to synovial fluid compared to indomethacin therapy.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/206
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/206/1/FksmJMedSci_53_p33.pdf
ISSN: 0016-2590
PubMed ID: 17957964
Rights: © 2007 The Fukushima Society of Medical Science
Appears in Collections:Vol.53 (2007)

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