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Vol.53 (2007) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/202

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Title: Ornithine decarboxylase activity as a prognostic marker for colorectal cancer
Other Titles: ODC activity as a prognostic marker
Authors: Hoshino, Yutaka
Terashima, Shinya
Teranishi, Yasushi
Terashima, Masanori
Kogure, Michihiko
Saitoh, Takuroh
Osuka, Fumihiko
Kashimura, Seigo
Saze, Zenichiroh
Gotoh, Mitsukazu
Affiliation: 外科学第一講座
Source title: Fukushima Journal of Medical Science
Volume: 53
Issue: 1
Start page: 1
End page: 9
Issue Date: Jun-2007
Abstract: Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. ODC activity was measured in 47 colorectal cancer patients, 5 patients with adenoma of colorectum and 4 healthy volunteers. Mean ODC activities of cancer tissue, non-cancerous mucosa from cancer-bearing colorectum, adenoma tissue, and normal mucosa from healthy volunteers were 435+/-392, 154+/-173, 295+/-202, 103+/-60 pmol CO2/h/mg protein, respectively. ODC activity of cancer tissue or adenoma tissue was significantly higher than that of the others. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. Patients with tumors that had high ODC activity (> or =350 pmol CO2/h/mg protein) showed a poor 10-year survival rate. These results suggest that ODC activity may be a useful marker for patients' prognosis after surgery.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/202
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/202/1/FksmJMedSci_53_p1.pdf
ISSN: 0016-2590
PubMed ID: 17957960
Rights: © 2007 The Fukushima Society of Medical Science
Appears in Collections:Vol.53 (2007)

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