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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.53 (2007) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/202
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| Title: | Ornithine decarboxylase activity as a prognostic marker for colorectal cancer |
| Other Titles: | ODC activity as a prognostic marker |
| Authors: | Hoshino, Yutaka
Terashima, Shinya
Teranishi, Yasushi
Terashima, Masanori
Kogure, Michihiko
Saitoh, Takuroh
Osuka, Fumihiko
Kashimura, Seigo
Saze, Zenichiroh
Gotoh, Mitsukazu |
| Affiliation: | 外科学第一講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 53 |
| Issue: | 1 |
| Start page: | 1 |
| End page: | 9 |
| Issue Date: | Jun-2007 |
| Abstract: | Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. ODC activity was measured in 47 colorectal cancer patients, 5 patients with adenoma of colorectum and 4 healthy volunteers. Mean ODC activities of cancer tissue, non-cancerous mucosa from cancer-bearing colorectum, adenoma tissue, and normal mucosa from healthy volunteers were 435+/-392, 154+/-173, 295+/-202, 103+/-60 pmol CO2/h/mg protein, respectively. ODC activity of cancer tissue or adenoma tissue was significantly higher than that of the others. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. Patients with tumors that had high ODC activity (> or =350 pmol CO2/h/mg protein) showed a poor 10-year survival rate. These results suggest that ODC activity may be a useful marker for patients' prognosis after surgery. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/202 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/202/1/FksmJMedSci_53_p1.pdf |
| ISSN: | 0016-2590 |
| PubMed ID: | 17957960 |
| Rights: | © 2007 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.53 (2007)
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