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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.52 (2006) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/197
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| タイトル: | Effects of fluvoxamine on behavioral and psychological symptoms of dementia in Alzheimer's disease: a report of three cases |
| その他のタイトル: | Effects of fluvoxamine on BPSD in AD |
| 著者: | Kurita, Masatake
Sato, Tadahiro
Nishino, Satoshi
Ohtomo, Koji
Shirakawa, Hisayoshi
Mashiko, Hirobumi
Niwa, Shin-Ichi
Nakahata, Norimichi |
| 学内所属: | 神経精神医学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 52 |
| 号: | 2 |
| 開始ページ: | 143 |
| 終了ページ: | 148 |
| 発行日: | 2006年12月 |
| 抄録: | OBJECTIVE: To report 3 cases of severe behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) with fluvoxamine treatment and to discuss the treatment implications for use of the drug. CASE SUMMARY: An 83-year-old woman was diagnosed with AD. Before treatment, she showed sudden irritation and excitement. Her BEHAVE-AD score was 40. She was started on fluvoxamine and quetiapine. Eight weeks later, she was friendly and thankful towards the staff. Her BEHAVE-AD score was 10. The second case was a 79-year-old woman diagnosed with AD. Before treatment, she attempted to leave our hospital and wandered and shouted throughout the day. Her BEHAVE-AD score was 42. She was started on fluvoxamine, and the dosage was gradually increased. Eight weeks later, the shouting and excitement disappeared almost completely. Her BEHAVE-AD score was 13. The third case was a 79-year-old man diagnosed with AD. Before treatment, we put him in a private, locked room because he was extremely agitated and violent because of delusions. His BEHAVE-AD score was 42. He was started on fluvoxamine and sodium valproate. Eight weeks later, the delusion became mild and did not affect his mood or behavior. His BEHAVE-AD score at this point was 4. DISCUSSION: Fluvoxamine was effective in controlling BPSD with AD. This finding shows that the pathophysiology of BPSD due to AD may occur because of a hyposerotonergic state in the brain. CONCLUSION: These cases show that fluvoxamine appears to be effective in the control of BPSD with AD. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/197 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/197/1/FksmJMedSci_52_p143.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.52.143 |
| PubMed番号: | 17427765 |
| 関連ページ: | https://doi.org/10.5387/fms.52.143 |
| 権利情報: | © 2006 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.52 (2006)
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