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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.52 (2006) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/197
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| Title: | Effects of fluvoxamine on behavioral and psychological symptoms of dementia in Alzheimer's disease: a report of three cases |
| Other Titles: | Effects of fluvoxamine on BPSD in AD |
| Authors: | Kurita, Masatake
Sato, Tadahiro
Nishino, Satoshi
Ohtomo, Koji
Shirakawa, Hisayoshi
Mashiko, Hirobumi
Niwa, Shin-Ichi
Nakahata, Norimichi |
| Affiliation: | 神経精神医学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 52 |
| Issue: | 2 |
| Start page: | 143 |
| End page: | 148 |
| Issue Date: | Dec-2006 |
| Abstract: | OBJECTIVE: To report 3 cases of severe behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) with fluvoxamine treatment and to discuss the treatment implications for use of the drug. CASE SUMMARY: An 83-year-old woman was diagnosed with AD. Before treatment, she showed sudden irritation and excitement. Her BEHAVE-AD score was 40. She was started on fluvoxamine and quetiapine. Eight weeks later, she was friendly and thankful towards the staff. Her BEHAVE-AD score was 10. The second case was a 79-year-old woman diagnosed with AD. Before treatment, she attempted to leave our hospital and wandered and shouted throughout the day. Her BEHAVE-AD score was 42. She was started on fluvoxamine, and the dosage was gradually increased. Eight weeks later, the shouting and excitement disappeared almost completely. Her BEHAVE-AD score was 13. The third case was a 79-year-old man diagnosed with AD. Before treatment, we put him in a private, locked room because he was extremely agitated and violent because of delusions. His BEHAVE-AD score was 42. He was started on fluvoxamine and sodium valproate. Eight weeks later, the delusion became mild and did not affect his mood or behavior. His BEHAVE-AD score at this point was 4. DISCUSSION: Fluvoxamine was effective in controlling BPSD with AD. This finding shows that the pathophysiology of BPSD due to AD may occur because of a hyposerotonergic state in the brain. CONCLUSION: These cases show that fluvoxamine appears to be effective in the control of BPSD with AD. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/197 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/197/1/FksmJMedSci_52_p143.pdf |
| ISSN: | 0016-2590 |
| PubMed ID: | 17427765 |
| Rights: | © 2006 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.52 (2006)
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