福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.52 (2006) >
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http://ir.fmu.ac.jp/dspace/handle/123456789/197
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Title: | Effects of fluvoxamine on behavioral and psychological symptoms of dementia in Alzheimer's disease: a report of three cases |
Other Titles: | Effects of fluvoxamine on BPSD in AD |
Authors: | Kurita, Masatake Sato, Tadahiro Nishino, Satoshi Ohtomo, Koji Shirakawa, Hisayoshi Mashiko, Hirobumi Niwa, Shin-Ichi Nakahata, Norimichi |
Affiliation: | 神経精神医学講座 |
Source title: | Fukushima Journal of Medical Science |
Volume: | 52 |
Issue: | 2 |
Start page: | 143 |
End page: | 148 |
Issue Date: | Dec-2006 |
Abstract: | OBJECTIVE: To report 3 cases of severe behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) with fluvoxamine treatment and to discuss the treatment implications for use of the drug. CASE SUMMARY: An 83-year-old woman was diagnosed with AD. Before treatment, she showed sudden irritation and excitement. Her BEHAVE-AD score was 40. She was started on fluvoxamine and quetiapine. Eight weeks later, she was friendly and thankful towards the staff. Her BEHAVE-AD score was 10. The second case was a 79-year-old woman diagnosed with AD. Before treatment, she attempted to leave our hospital and wandered and shouted throughout the day. Her BEHAVE-AD score was 42. She was started on fluvoxamine, and the dosage was gradually increased. Eight weeks later, the shouting and excitement disappeared almost completely. Her BEHAVE-AD score was 13. The third case was a 79-year-old man diagnosed with AD. Before treatment, we put him in a private, locked room because he was extremely agitated and violent because of delusions. His BEHAVE-AD score was 42. He was started on fluvoxamine and sodium valproate. Eight weeks later, the delusion became mild and did not affect his mood or behavior. His BEHAVE-AD score at this point was 4. DISCUSSION: Fluvoxamine was effective in controlling BPSD with AD. This finding shows that the pathophysiology of BPSD due to AD may occur because of a hyposerotonergic state in the brain. CONCLUSION: These cases show that fluvoxamine appears to be effective in the control of BPSD with AD. |
Publisher: | The Fukushima Society of Medical Science |
Publisher (Alternative foam): | 福島医学会 |
language: | eng |
URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/197 |
Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/197/1/FksmJMedSci_52_p143.pdf |
ISSN: | 0016-2590 |
DOI: | 10.5387/fms.52.143 |
PubMed ID: | 17427765 |
Related Page: | https://doi.org/10.5387/fms.52.143 |
Rights: | © 2006 The Fukushima Society of Medical Science |
Appears in Collections: | Vol.52 (2006)
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