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福島医学会 = The Fukushima Society of Medical Science >
福島医学雑誌 = Fukushima Medical Journal >
Vol.73 (2023) >
Vol.73 No.1 (2023) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1965

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Title: Vater乳頭部癌を合併したLynch症候群の1例
Other Titles: Cancer of the ampulla of vater in lynch syndrome : a case report
Authors: 菅家, 康之
伊藤, 泰輔
菅原, 良太
東條, 華子
藤田, 正太郎
八島, 玲
勝部, 暢介
田畑, 憲一
野水, 整
Source title: 福島医学雑誌
Volume: 73
Issue: 1
Start page: 13
End page: 18
Issue Date: 2023
Abstract: 症例は56歳男性で貧血,肝機能障害,大腸ポリープを認め当院を受診した。41歳時に直腸癌にて直腸切断術の既往あり,大腸癌家族歴は認めず。今回多発する大腸癌,Vater乳頭部癌に対して手術を施行した。免疫染色にて癌病変部においてMSH2タンパクおよびMSH6タンパクの欠失を認めた。遺伝学的検査にてhMSH2遺伝子の生殖細胞系列変異が認められLynch 症候群と診断した。今回の症例について若干の文献的考察を加えて報告する。
A 56-years-old male presented at our hospital due to the symptoms of anemia, liver disfunction and colon polyps. He had resected rectal cancer at the ages of 41 and has no family history of colorectal cancer. A thorough examination for anemia resulted in detection of multiple colon cancer and cancer on ampulla of Vater. We performed total colectomy with dissection of regional lymph nodes and pancreaticoduodenectomy with dissection of regional lymph nodes. Immunohistochemical analysis showed a lack of MSH2 and MSH6 protein in the colon cancer and cancer on ampulla of Vater, and germline mutation of hMSH2 gene was recognized. Therefore, we diagnosed the case as Lynch syndrome.
Publisher: 福島医学会
language: jpn
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1965
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1965/1/FksmMedJ_73_p13.pdf
ISSN: 0016-2582
DOI: 10.5387/fmedj.73.1_13
Related Page: https://doi.org/10.5387/fmedj.73.1_13
Rights: © 2023 福島医学会
Appears in Collections:Vol.73 No.1 (2023)

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