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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.69 (2023) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/1956
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| Title: | Investigation of biomarkers in a rare case of fulminant necrotizing enterocolitis in a preterm infant |
| Authors: | Nakamura, Toshihiko
Inoue, Shota
Ito, Kana
Fukama, Eisuke
Nomura, Tomoaki
Hatanaka, Daisuke
Kusakari, Michiko
Takahashi, Hidehiro
Yamada, Shingo |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 69 |
| Issue: | 1 |
| Start page: | 29 |
| End page: | 36 |
| Issue Date: | 2023 |
| Abstract: | We encountered a very rare case of fulminant necrotizing enterocolitis (F-NEC) in a preterm male baby. The course of NEC and sepsis in this case was clearly different from the usual course. After onset at 14 days of life, catheter-related bloodstream infection was first assumed, and antibiotics and γ-globulin administration were started. However, 12 hours after onset, the baby's abdominal distension increased remarkably, and his entire abdominal wall turned red to purple. Escherichia coli were isolated from the blood culture, but the catheter tip culture was negative. Exchange transfusion was performed 32 hours after onset, but no significant changes were observed in the baby's general condition, and he died 46 hours after onset. The acute phase reactants of CRP and α1-acid glycoprotein increased, but haptoglobin did not. Although IL-1β and TNFα increased as expected with sepsis, IL-6, IL-8, IL-10, and G-CSF however increased to a greater extent than expected. From the above, we diagnosed the development of intestinal necrosis as a result of widespread intestinal ischemia, and that sepsis was associated with this poor condition. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1956 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1956/1/FksmJMedSci_69_p29.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2022-25 |
| PubMed ID: | 36631077 |
| Related Page: | https://doi.org/10.5387/fms.2022-25 |
| Rights: | © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.69 (2023)
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