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Vol.52 (2006) >

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Title: Usefulness of complement split product, Bb, as a clinical marker for disease activity of lupus nephritis
Authors: Watanabe, Hiroshi
Noguchi, Etsuko
Shio, Kiori
Iwadate, Haruyo
Kobayashi, Hiroko
Ohira, Hiromasa
Affiliation: 内科学第二講座
Source title: Fukushima Journal of Medical Science
Volume: 52
Issue: 2
Start page: 103
End page: 109
Issue Date: Dec-2006
Abstract: To evaluate the usefulness of Bb, a split product of complement factor B, as a clinical marker for disease activity of lupus nephritis, we measured the Bb concentration of sera from 42 patients with lupus nephritis. Serum Bb levels were significantly higher in patients with active nephritis (active nephritis group, n= 30) than in patients with nephritis in remission (remission group, n=12) (14.3+/-8.3 versus 7.4+/-5.9 microg/ml; p = 0.012). In contrast, there was no significant difference in serum C3 levels between active nephritis group and remission group (42.5+/-20.9 versus 44.7+/-15.9 mg/dl ; p = 0.77). In the comparison of Bb levels between active nephritis group and remission group, the sensitivity was 66.6%, specificity was 83.3%, and the positive and negative likelihood ratios were 3.95% and 0.41%, respectively. The present results suggest that serum Bb level is a useful clinical marker for disease activity in lupus nephritis.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/193
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/193/1/FksmJMedSci_52_p103.pdf
ISSN: 0016-2590
PubMed ID: 17427761
Rights: © 2006 The Fukushima Society of Medical Science
Appears in Collections:Vol.52 (2006)

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