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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.52 (2006) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/191
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| タイトル: | Possible association of cytotoxic T lymphocyte antigen-4 genetic polymorphism with liver damage of primary biliary cirrhosis in Japan |
| その他のタイトル: | CTLA-4 polymorphism in patients with PBC |
| 著者: | Kanno, Yukiko
Rai, Tsuyoshi
Monoe, Kyoko
Saito, Hironobu
Takahashi, Atsushi
Irisawa, Atsushi
Ohira, Hiromasa |
| 学内所属: | 内科学第二講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 52 |
| 号: | 2 |
| 開始ページ: | 79 |
| 終了ページ: | 85 |
| 発行日: | 2006年12月 |
| 抄録: | Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an important inhibitor of T-lymphocyte response. Polymorphisms in the CTLA-4 gene have been reported to be associated with numerous autoimmune diseases. The aim of this study was to determine whether polymorphisms of CTLA-4 exon 1 (+49) genes are associated with susceptibility and clinicolaboratory findings of primary biliary cirrhosis (PBC) in the Japanease population. Blood samples were obtained from 45 patients (6 men and 39 women, aged 23-56 years) with PBC and 73 healthy controls (48 men and 25 women, aged 22-72 years). CTLA-4 exon 1 (+49) polymorphism was defined using a polymerase chain reaction-restriction fragment length polymorphism with Bst71I restriction enzyme. The genotype frequencies of A/A, A/G, and G/G in 45 patients with PBC were 11% (5 patients), 44% (20 patients), and 44% (20 patients), respectively. There was no significant difference between frequencies in PBC patients and healthy controls. PBC patients with G/G genotype had significantly higher serum levels of ALT, GGT, and IgM than those in patients with A/A or A/G genotype. In conclusion, CTLA-4 gene polymorphisms are not associated with susceptibility of PBC in Japan; however, G/G genotype may be associated with liver damage. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/191 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/191/1/FksmJMedSci_52_p79.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.52.79 |
| PubMed番号: | 17427759 |
| 関連ページ: | https://doi.org/10.5387/fms.52.79 |
| 権利情報: | © 2006 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.52 (2006)
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