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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/19

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Title: Delayed and acute hemolytic transfusion reactions due to red cell antibodies and red cell-reactive HLA antibodies
Authors: Takeuchi, Chikako
Ohto, Hitoshi
Miura, Saori
Yasuda, Hiroyasu
Ono, Satoshi
Ogata, Takashi
Affiliation: 輸血・移植免疫部
Source title: Transfusion
Volume: 45
Issue: 12
Start page: 1925
End page: 1929
Issue Date: Dec-2005
Abstract: Background:It has been controversial whether HLA antibodies cause hemolytic transfusion reactions (HTR) or shortened RBC survival. We report a patient who had two episodes of HTR, the latter of which was likely due to RBC-reactive HLA antibodies. Case Report:A 77-year-old woman, admitted for gastric varix rupture, had no RBC irregular antibodies detected before transfusion. On hospital day 12, after transfusion of two units of RBCs and two units of FFP, the first delayed hemolytic episode occurred and anti-E, anti-c, anti-Jka and unidentified RBC-reactive antibodies were detected in serum from day 14. Two further units of compatible RBCs were transfused using a leukocyte-reduction filter on days 19 and 22. After 4 hours of starting a transfusion on day 22, the patient had fever, and a second hemolytic episode was recorded. Multireactive HLA antibodies (reactive against 20 of 20 donor panel lymphocytes) were detected in sera from day 15 to day 21. These HLA antibodies reacted strongly with HLA-A2 and HLA-B7 antigens, corresponding to Bgc and Bga antigens on RBCs, respectively. RBCs transfused on day 22 were found to be HLA-A2 by genotyping. Conclusion: Strong HLA alloantibodies in this recipient appear to have caused a HTR. It is suggested that HLA antibodies be considered in patients with unexplained HTRs.
Publisher: Blackwell Publishing Inc.
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/19
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/19/1/Transfusion_45_1925.pdf
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2005.00607.x
PubMed ID: 16371045
Other version: http://dx.doi.org/10.1111/j.1537-2995.2005.00607.x
Rights: © 2005 American Association of Blood Banks. The definitive version is available at www.blackwell-synergy.com.
Appears in Collections:a10 学術雑誌論文等 = Journal Article

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