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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
A 医学部 = School of Medicine >
a10 学術雑誌論文等 = Journal Article >
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http://ir.fmu.ac.jp/dspace/handle/123456789/19
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| タイトル: | Delayed and acute hemolytic transfusion reactions due to red cell antibodies and red cell-reactive HLA antibodies |
| 著者: | Takeuchi, Chikako
Ohto, Hitoshi
Miura, Saori
Yasuda, Hiroyasu
Ono, Satoshi
Ogata, Takashi |
| 学内所属: | 輸血・移植免疫部 |
| 誌名/書名: | Transfusion |
| 巻: | 45 |
| 号: | 12 |
| 開始ページ: | 1925 |
| 終了ページ: | 1929 |
| 発行日: | 2005年12月 |
| 抄録: | Background：It has been controversial whether HLA antibodies cause hemolytic transfusion reactions (HTR) or shortened RBC survival. We report a patient who had two episodes of HTR, the latter of which was likely due to RBC-reactive HLA antibodies. Case Report：A 77-year-old woman, admitted for gastric varix rupture, had no RBC irregular antibodies detected before transfusion. On hospital day 12, after transfusion of two units of RBCs and two units of FFP, the first delayed hemolytic episode occurred and anti-E, anti-c, anti-Jka and unidentified RBC-reactive antibodies were detected in serum from day 14. Two further units of compatible RBCs were transfused using a leukocyte-reduction filter on days 19 and 22. After 4 hours of starting a transfusion on day 22, the patient had fever, and a second hemolytic episode was recorded. Multireactive HLA antibodies (reactive against 20 of 20 donor panel lymphocytes) were detected in sera from day 15 to day 21. These HLA antibodies reacted strongly with HLA-A2 and HLA-B7 antigens, corresponding to Bgc and Bga antigens on RBCs, respectively. RBCs transfused on day 22 were found to be HLA-A2 by genotyping.
Conclusion： Strong HLA alloantibodies in this recipient appear to have caused a HTR. It is suggested that HLA antibodies be considered in patients with unexplained HTRs. |
| 出版者: | Blackwell Publishing Inc. |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/19 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/19/1/Transfusion_45_1925.pdf |
| ISSN: | 0041-1132 |
| DOI: | 10.1111/j.1537-2995.2005.00607.x |
| PubMed番号: | 16371045 |
| 異版(出版者版等): | http://dx.doi.org/10.1111/j.1537-2995.2005.00607.x |
| 権利情報: | © 2005 American Association of Blood Banks. The definitive version is available at www.blackwell-synergy.com. |
| 出現コレクション: | a10 学術雑誌論文等 = Journal Article
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