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Vol.52 (2006) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/189

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Title: Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis
Other Titles: hGR-β in patients with severe AIH
Authors: Rai, Tsuyoshi
Monoe, Kyoko
Kanno, Yukiko
Saito, Hironobu
Takahashi, Atsushi
Irisawa, Atsushi
Ohira, Hiromasa
Affiliation: 内科学第二講座
Source title: Fukushima Journal of Medical Science
Volume: 52
Issue: 2
Start page: 65
End page: 70
Issue Date: Dec-2006
Abstract: We evaluated the expression of human glucocorticoid receptor beta (hGRbeta) in patients with severe autoimmune hepatitis (AIH). The subjects were 27 patients with AIH, including 6 with severe type (prothrombin time [PT] < 40%) and 21 with non-severe type (PT>40%). Total RNA extracted from peripheral blood mononuclear cells (PBMCs) was reversed using reverse transcriptase. The resultant complementary DNA was amplified by reverse transcription polymerase chain reaction (RT-PCR) using specific primers for hGR alpha and beta. The six patients with severe AIH were female; three presented fulminant hepatic failure with hepatic encephalopathy. In all patients with AIH, hGR a was detected. The incidence of hGR beta expression in patients with non-severe type was 42.9% (9/21) ; it was 100% (6/6) in those with severe type. The positive ratio was significantly higher in severe-type patients. These results suggest that hGR beta expression in PBMCs is a novel predictor of AIH severity.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/189
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/189/1/FksmJMedSci_52_p65.pdf
ISSN: 0016-2590
PubMed ID: 17427757
Rights: © 2006 The Fukushima Society of Medical Science
Appears in Collections:Vol.52 (2006)

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FksmJMedSci_52_p65.pdf673.86 kBAdobe PDFDownload

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