|
福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.52 (2006) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/189
|
| Title: | Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis |
| Other Titles: | hGR-β in patients with severe AIH |
| Authors: | Rai, Tsuyoshi
Monoe, Kyoko
Kanno, Yukiko
Saito, Hironobu
Takahashi, Atsushi
Irisawa, Atsushi
Ohira, Hiromasa |
| Affiliation: | 内科学第二講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 52 |
| Issue: | 2 |
| Start page: | 65 |
| End page: | 70 |
| Issue Date: | Dec-2006 |
| Abstract: | We evaluated the expression of human glucocorticoid receptor beta (hGRbeta) in patients with severe autoimmune hepatitis (AIH). The subjects were 27 patients with AIH, including 6 with severe type (prothrombin time [PT] < 40%) and 21 with non-severe type (PT>40%). Total RNA extracted from peripheral blood mononuclear cells (PBMCs) was reversed using reverse transcriptase. The resultant complementary DNA was amplified by reverse transcription polymerase chain reaction (RT-PCR) using specific primers for hGR alpha and beta. The six patients with severe AIH were female; three presented fulminant hepatic failure with hepatic encephalopathy. In all patients with AIH, hGR a was detected. The incidence of hGR beta expression in patients with non-severe type was 42.9% (9/21) ; it was 100% (6/6) in those with severe type. The positive ratio was significantly higher in severe-type patients. These results suggest that hGR beta expression in PBMCs is a novel predictor of AIH severity. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/189 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/189/1/FksmJMedSci_52_p65.pdf |
| ISSN: | 0016-2590 |
| PubMed ID: | 17427757 |
| Rights: | © 2006 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.52 (2006)
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|
