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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.52 (2006) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/186
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| タイトル: | The role of FB21 as a marker of glomerular endothelial cell injury |
| その他のタイトル: | Role of FB21 |
| 著者: | Kawasaki, Yukihiko |
| 学内所属: | 小児科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 52 |
| 号: | 2 |
| 開始ページ: | 35 |
| 終了ページ: | 43 |
| 発行日: | 2006年12月 |
| 抄録: | FB21 was reactive with the glomerular endothelial cells and distal tubules of the human kidney and was bound to a sialic-acid-dependent cell surface antigen. We evaluated the FB21 staining in fetal kidneys, and the kidneys of children and adults with normal kidneys and glomerulonephritis and investigated whether FB21 can be used as a marker for endothelial cell injury. FB21 was reactive with the endothelial cells of normal kidneys and was detected on the surface of endothelial cells by immunoelectron microscopy. FB21 was reactive with endothelial cells in the kidneys of over 32-week fetuses. The endothelial cell FB21 staining scores in the first renal biopsy specimens of patients with hemolytic uremic syndrome (HUS) were lower than in the kidneys of children with normal kidneys and was negatively correlated with their serum E-selectin concentrations. The FB21 staining of glomerular endothelial cells was similar to the staining for the other endothelial markers, CD34 and von Willebrand factor (vWF). However, FB21 staining of interstitial blood vessels was very weak and was distinct from that of other endothelial markers. These results suggest that FB21 can be used as a specific marker for glomerular endothelial cell injury in various types of glomerulonephritis. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/186 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/186/1/FksmJMedSci_52_p35.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.52.35 |
| PubMed番号: | 17427754 |
| 関連ページ: | https://doi.org/10.5387/fms.52.35 |
| 権利情報: | © 2006 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.52 (2006)
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