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Title: Survival and recovery of apheresis platelets stored in a polyolefin container with high oxygen permeability
Authors: Ezuki, Shoji
Kanno, Takahiro
Ohto, Hitoshi
Herschel, Louise
Ito, Takatoshi
Kawabata, Kinuyo
Seino, Osamu
Ikeda, Kazuhiko
Nollet, Kenneth E
Affiliation: 輸血・移植免疫部
放射線医学講座
Source title: Vox Sanguinis
Volume: 94
Issue: 4
Start page: 292
End page: 298
Issue Date: May-2008
Abstract: Background and Objectives Oxygen permeability is important in platelet storage media. We compared a new polyolefin container with enhanced oxygen permeability (PO-80, Kawasumi, Tokyo, Japan) to a widely used alternative (PL2410, Baxter Healthcare, Illinois, USA). Materials and Methods In vitro characteristics of paired platelet concentrates (PCs, mean 4.2×1011/250 ml plasma/bag) stored in PO-80 or PL2410 were assessed through nine days of storage. In vivo recovery and survival of seven-day-old autologous PCs were assessed according to the Murphy method. Results Laboratory assessment of platelet quality favored PO-80 during nine days of storage with statistically significant differences in glucose consumption (2.75 vs. 4.93 mmol/1012/24hrs in the interval 120-168 hrs), lactate generation (4.37 vs. 8.11 mmol/1012/24hrs in the interval 120-168 hrs), pO2 (59.3 vs. 38.1 mmHg at day 1), and HCO3- (14.7 vs. 13.4 mmol/L at day 1). Statistically significant differences were not seen in aggregation, hypotonic shock response, or pH. In vivo assessment of autologous platelets stored seven days in the PO-80 container revealed that recovery was 82.1% and survival was 81.0% of fresh control. Seven-day-stored PCs in PO-80 were shown in vivo to be noninferior to fresh platelets, with upper confidence limits (UCL95) in recovery and survival of stored PCs below the maximum acceptable difference (MAD); 15.3% UCL95 < 20.4% MAD and 2.1 days UCL95 < 2.1 days MAD. Conclusions The in vitro characteristics of PCs stored in a highly oxygen-permeable container were stable at least seven days. The in vivo study supports the suitability of PO-80 for seven-day platelet storage.
Publisher: Blackwell Publishing Ltd.
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/18
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/18/1/VoxSang_94_292.pdf
ISSN: 0042-9007
1423-0410
DOI: 10.1111/j.1423-0410.2008.01042.x
PubMed ID: 18331381
Other version: http://dx.doi.org/10.1111/j.1423-0410.2008.01042.x
Rights: Journal compilation © 2008 Blackwell Publishing Ltd. The definitive version is available at www.blackwell-synergy.com
Appears in Collections:a10 学術雑誌論文等 = Journal Article

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