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Vol.51 (2005) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/172

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Title: Roles of RAS and BRAF mutations in thyroid carcinogenesis
Other Titles: BRAF mutations in thyroid cancer
Authors: Fukushima, Toshihiko
Takenoshita, Seiichi
Affiliation: 外科学第二講座
Source title: Fukushima Journal of Medical Science
Volume: 51
Issue: 2
Start page: 67
End page: 75
Issue Date: Dec-2005
Abstract: Papillary carcinoma and follicular carcinoma are types of differentiated thyroid carcinomas, develop from the same thyroid follicular epithelial cells and show distinct biological behavior. Although several studies have demonstrated differences in the biological characteristics of these carcinomas, little is known about the genetic backgrounds that underlie these differences. The clarification of the genetic background can lead to the understanding of thyroid carcinogenesis, proper therapeutic strategies, and development of the molecular targeting drugs. Recently, aberrant activation of RAS-RAF-MEK-MAP kinase signaling pathway is frequently found in thyroid carcinoma. The pathway transmits a mitogenic signal to the nucleus, and constitutive activation of the pathway is thought to promote uncontrolled cell division. In our series, BRAF mutation was detected exclusively in papillary carcinoma (54%), and was exclusively V599E (a single nucleotide change of A-T at nucleotide 1796). NRAS mutation was observed in follicular carcinoma (50%) and in anaplastic carcinoma (28%), and was exclusively Q61R (a single nucleotide change of A-G at nucleotide 182). No mutations were found in KRAS or HRAS. In this chapter, we explain the role of RAS-RAF-MEK-MAP kinase pathway in carcinogenesis of the thyroid and its clinical implication based on our study. In addition, we review the current knowledge in this field.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/172
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/172/1/FksmJMedSci_51_p67.pdf
ISSN: 0016-2590
PubMed ID: 16555627
Rights: © 2005 The Fukushima Society of Medical Science
Appears in Collections:Vol.51 (2005)

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