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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.51 (2005) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/172
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| タイトル: | Roles of RAS and BRAF mutations in thyroid carcinogenesis |
| その他のタイトル: | BRAF mutations in thyroid cancer |
| 著者: | Fukushima, Toshihiko
Takenoshita, Seiichi |
| 学内所属: | 外科学第二講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 51 |
| 号: | 2 |
| 開始ページ: | 67 |
| 終了ページ: | 75 |
| 発行日: | 2005年12月 |
| 抄録: | Papillary carcinoma and follicular carcinoma are types of differentiated thyroid carcinomas, develop from the same thyroid follicular epithelial cells and show distinct biological behavior. Although several studies have demonstrated differences in the biological characteristics of these carcinomas, little is known about the genetic backgrounds that underlie these differences. The clarification of the genetic background can lead to the understanding of thyroid carcinogenesis, proper therapeutic strategies, and development of the molecular targeting drugs. Recently, aberrant activation of RAS-RAF-MEK-MAP kinase signaling pathway is frequently found in thyroid carcinoma. The pathway transmits a mitogenic signal to the nucleus, and constitutive activation of the pathway is thought to promote uncontrolled cell division. In our series, BRAF mutation was detected exclusively in papillary carcinoma (54%), and was exclusively V599E (a single nucleotide change of A-T at nucleotide 1796). NRAS mutation was observed in follicular carcinoma (50%) and in anaplastic carcinoma (28%), and was exclusively Q61R (a single nucleotide change of A-G at nucleotide 182). No mutations were found in KRAS or HRAS. In this chapter, we explain the role of RAS-RAF-MEK-MAP kinase pathway in carcinogenesis of the thyroid and its clinical implication based on our study. In addition, we review the current knowledge in this field. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/172 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/172/1/FksmJMedSci_51_p67.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.51.67 |
| PubMed番号: | 16555627 |
| 関連ページ: | https://doi.org/10.5387/fms.51.67 |
| 権利情報: | © 2005 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.51 (2005)
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