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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.50 (2004) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/158
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| タイトル: | A comparative study on contractile responses of rabbit and guinea pig vasa deferentia to electrical field stimulation |
| その他のタイトル: | Rabbit and guinea pig vasa deferentia |
| 著者: | Nakanishi, Hironori
Ohkubo, Satoko
Ono, Tomoyuki
Matsuoka, Isao
Nakahata, Norimichi |
| 学内所属: | 薬理学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 50 |
| 号: | 2 |
| 開始ページ: | 55 |
| 終了ページ: | 64 |
| 発行日: | 2004年12月 |
| 抄録: | Contractile responses of rabbit and guinea pig vasa deferentia to electrical field stimulation (EFS) are compared. A muscarinic receptor blocking agent, 1 microM atropine markedly reduced phasic and tonic contraction induced by EFS (20 Hz, 0.5 msec, 30 V, for 30 sec) in rabbit vas deferens, while it only slightly depressed those in guinea pig vas deferens. Further addition of an adrenergic alpha1 receptor blocking agent, 1 microM prazosin markedly depressed the second tonic contraction in both rabbit and guinea pig vasa deferentia. In the presence of atropine and prazosin, further addition of a P2X purinoceptor desensitizing agent, 10 microM alpha,beta-methylene ATP (alpha, beta-MeATP) abolished the residual phasic contractile response in guinea pig vas deferens, while it partially depressed that in rabbit vas deferens. The administration of 10 microM alpha,beta-MeATP in the absence of atropine and prazosin markedly potentiated the phasic contractile response of rabbit vas deferens to EFS, while it depressed that of guinea pig vas deferens. Contractile response of rabbit vas deferens to alpha,beta-MeATP was more potent than those of ATP and 2-methyl-thioATP (2-Me-thioATP), while these nucleotides had almost same potency in guinea pig vas deferens. These findings may indicate that contribution of cholinergic, adrenergic and purinergic neurotransmission to the contractile response of rabbit vas deferens to EFS is different from that of guinea pig vas deferens. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/158 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/158/1/FksmJMedSci_50_p55.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.50.55 |
| PubMed番号: | 15779571 |
| 関連ページ: | https://doi.org/10.5387/fms.50.55 |
| 権利情報: | © 2004 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.50 (2004)
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