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Vol.66 (2020) >

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Title: Early intra-abdominal infection following pancreaticoduodenectomy:associated factors and clinical impact on surgical outcome
Authors: Sato, Naoya
Kimura, Takashi
Kenjo, Akira
Kofunato, Yasuhide
Okada, Ryo
Ishigame, Teruhide
Watanabe, Junichiro
Marubashi, Shigeru
Affiliation: 肝胆膵・移植外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 66
Issue: 3
Start page: 124
End page: 132
Issue Date: 2020
Abstract: Early intra-abdominal infection (IAI) following pancreaticoduodenectomy (PD) is an initial event relating to morbidities caused by postoperative pancreatic fistula (POPF). The aims of this study were to determine factors associated with IAI, and to investigate its impact on postoperative outcome.Consecutive patients, 113 in total, who underwent PD at Fukushima Medical University Hospital between January 2012 and September 2017 were included in this retrospective study. IAI was defined by positive bacterial culture from intra-abdominal drainage fluid any time through postoperative day 3 (POD3). Logistic regression analysis was used to identify the relevant factors associated with IAI. The clinical impact of the POD3 infection indicators related to POPF were assessed by multivariate analysis.The incidence of IAI, POPF, and mortality were 36.1%, 36.1%, and 0%, respectively. Independent factors associated with IAI were preoperative biliary drainage (PBD) (OR = 2.91, CI = 1.16-7.33, p = 0.023) and soft pancreas (OR = 8.67, CI = 2.37-31.77, p = 0.001). Among infection markers on POD3, the significant factors for POPF were CRP (OR = 1.18, CI = 1.08-1.30, p < 0.001), IAI (OR = 7,37, CI = 2.53-21.5, p < 0.001), and drain amylase (OR = 1.00, CI = 1.00-1.01, p = 0.001).In conclusion, PBD, soft pancreas, and higher age were associated with IAI. IAI has a significantly negative impact on postoperative outcome.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1355
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1355/1/FksmJMedSci_66_p124.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2020-11
PubMed ID: 32963204
Related Page: https://doi.org/10.5387/fms.2020-11
Rights: © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.66 (2020)

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FksmJMedSci_66_p124.pdf256.66 kBAdobe PDFDownload

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