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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.66 (2020) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/1355
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| Title: | Early intra-abdominal infection following pancreaticoduodenectomy:associated factors and clinical impact on surgical outcome |
| Authors: | Sato, Naoya
Kimura, Takashi
Kenjo, Akira
Kofunato, Yasuhide
Okada, Ryo
Ishigame, Teruhide
Watanabe, Junichiro
Marubashi, Shigeru |
| Affiliation: | 肝胆膵・移植外科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 66 |
| Issue: | 3 |
| Start page: | 124 |
| End page: | 132 |
| Issue Date: | 2020 |
| Abstract: | Early intra-abdominal infection (IAI) following pancreaticoduodenectomy (PD) is an initial event relating to morbidities caused by postoperative pancreatic fistula (POPF). The aims of this study were to determine factors associated with IAI, and to investigate its impact on postoperative outcome.Consecutive patients, 113 in total, who underwent PD at Fukushima Medical University Hospital between January 2012 and September 2017 were included in this retrospective study. IAI was defined by positive bacterial culture from intra-abdominal drainage fluid any time through postoperative day 3 (POD3). Logistic regression analysis was used to identify the relevant factors associated with IAI. The clinical impact of the POD3 infection indicators related to POPF were assessed by multivariate analysis.The incidence of IAI, POPF, and mortality were 36.1%, 36.1%, and 0%, respectively. Independent factors associated with IAI were preoperative biliary drainage (PBD) (OR = 2.91, CI = 1.16-7.33, p = 0.023) and soft pancreas (OR = 8.67, CI = 2.37-31.77, p = 0.001). Among infection markers on POD3, the significant factors for POPF were CRP (OR = 1.18, CI = 1.08-1.30, p < 0.001), IAI (OR = 7,37, CI = 2.53-21.5, p < 0.001), and drain amylase (OR = 1.00, CI = 1.00-1.01, p = 0.001).In conclusion, PBD, soft pancreas, and higher age were associated with IAI. IAI has a significantly negative impact on postoperative outcome. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1355 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1355/1/FksmJMedSci_66_p124.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2020-11 |
| PubMed ID: | 32963204 |
| Related Page: | https://doi.org/10.5387/fms.2020-11 |
| Rights: | © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.66 (2020)
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