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Vol.66 (2020) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1324

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Title: Cesium suppresses fibroblast proliferation and migration
Authors: Khatun, Ziasmin
Nishimura, Natsumi
Kobayashi, Daisuke
Hazama, Akihiro
Affiliation: 細胞統合生理学講座
Source title: Fukushima Journal of Medical Science
Volume: 66
Issue: 2
Start page: 97
End page: 102
Issue Date: 2020
Abstract: During wound healing, fibroblasts proliferate from the margin, and migrate into the provisional matrix where they differentiate into myofibroblasts resulting in wound contraction; however, fibroblasts are hyperproliferative during chronic tissue damage. We previously reported that cesium chloride inhibited a human cancer cell proliferation; therefore, cesium is also presumed to suppress fibroblast proliferation. We here investigated the effects of cesium chloride on the proliferation and migration of murine embryotic fibroblast cells, NIH/3T3 cells. Cultured NIH/3T3 cells with 0-10 mM sodium and cesium chloride were counted using trypan blue dye-exclusion method, then cell growth and viability were evaluated. The percentage of wound closure was calculated by scratch assay. The number of the cells was decreased by application of 1-10 mM cesium in a dose-dependent manner, whereas the viability of the cells was unchanged. The treatment with 3-10 mM cesium inhibited the proliferation rate and % of wound closure compared with controls. These results suggested that cesium inhibits the proliferation and migration of fibroblast cells. This study indicates a possible therapeutic role of cesium chloride in the treatment of wound healing and fibrosis.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1324
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1324/1/FksmJMedSci_66_p97.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2020-08
PubMed ID: 32624528
Related Page: https://doi.org/10.5387/fms.2020-08
Rights: © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.66 (2020)

Files in This Item:

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FksmJMedSci_66_p97.pdf913.94 kBAdobe PDFDownload

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