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Vol.66 (2020) >

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Title: Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer
Authors: Sakamoto, Wataru
Ohki, Shinji
Kikuchi, Tomohiro
Okayama, Hirokazu
Fujita, Shotaro
Endo, Hisahito
Saito, Motonobu
Saze, Zenichiro
Momma, Tomoyuki
Kono, Koji
Affiliation: 消化管外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 66
Issue: 1
Start page: 10
End page: 16
Issue Date: 2020
Abstract: Objective: Anastomotic leakage (AL) is one of the most devastating complications of rectal cancer surgery. Not only does AL result in reduced quality of life, extended hospitalization and impaired defecatory function, it also has a high local recurrence rate. In this study, we investigated risk factors for AL as it may help to decrease its occurrence and improve patient outcomes. Methods: This study was a retrospective, single-institution study of rectal cancer patients who underwent elective low anterior resection between April 2002 and February 2018 at Fukushima Medical University Hospital. Patients were divided into two groups according to the presence of AL. Patient-, tumor-, and surgery-related variables were examined using univariate and multivariate analyses. Results: One hundred sixty-one patients, average age 63.5±11.5 years, were enrolled in the study. The overall AL rate was 6.8% (11/161). In the univariate analysis, modified Glasgow Prognostic Score (mGPS)=2 (p=0.003), use of multiple staplers (≥3 firings) for rectal transection (p=0.001) and intraoperative bleeding (≥250 g) were significantly associated with AL incidence. Multivariate analysis identified that mGPS = 2 (odds ratio [OR]: 19.6, 95% confidence interval [CI]: 2.96-125.00, p=0.002) and multiple firings (OR: 18.19, CI: 2.31-111.11, p=0.002) were independent risk factors for AL. Conclusion: Higher mGPS score and multiple firings were independent risk factors for AL.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1310
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1310/1/FksmJMedSci_66_p10.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2019-17
PubMed ID: 32074522
Related Page: https://doi.org/10.5387/fms.2019-17
Rights: © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.66 (2020)

Files in This Item:

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FksmJMedSci_66_p10.pdf345.98 kBAdobe PDFDownload

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