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Vol.66 (2020) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1309

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Title: Autoantibodies associated with neuropsychiatric systemic lupus erythematosus: the quest for symptom-specific biomarkers
Authors: Sato, Shuzo
Temmoku, Jumpei
Fujita, Yuya
Yashiro-Furuya, Makiko
Matsuoka, Naoki
Asano, Tomoyuki
Kobayashi, Hiroko
Watanabe, Hiroshi
Migita, Kiyoshi
Affiliation: リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 66
Issue: 1
Start page: 1
End page: 9
Issue Date: 2020
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs, including the central nervous system. Neuropsychiatric SLE (NPSLE) is a severe and potentially fatal condition. Several factors including autoantibodies have been implicated in the pathogenesis of NPSLE. However, definitive biomarkers of NPSLE are yet to be identified owing to the complexity of this disease. This is a major barrier to accurate and timely diagnosis of NPSLE. Studies have identified several autoantibodies associated with NPSLE; some of these autoantibodies are well investigated and regarded as symptom-specific. In this review, we discuss recent advances in our understanding of the manifestations and pathogenesis of NPSLE. In addition, we describe representative symptom-specific autoantibodies that are considered to be closely associated with the pathogenesis of NPSLE.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1309
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1309/1/FksmJMedSci_66_p1.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2020-02
PubMed ID: 32173681
Related Page: https://doi.org/10.5387/fms.2020-02
Rights: © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.66 (2020)

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FksmJMedSci_66_p1.pdf389.04 kBAdobe PDFDownload

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