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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/125

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Title: High Serum Level of Neopterin is a Risk Factor of Patients with Heart Failure
Other Titles: Neopterin in heart failure
Authors: Sasaki, Toshiki
Takeishi, Yasuchika
Suzuki, Satoshi
Niizeki, Takeshi
Kitahara, Tatsuro
Katoh, Shigehiko
Ishino, Mitsunori
Shishido, Tetsuro
Watanabe, Tetsu
Kubota, Isao
Affiliation: 循環器・血液内科学講座
Source title: International Journal of Cardiology
Volume: 145
Issue: 2
Start page: 318
End page: 318
Issue Date: 19-Nov-2010
Abstract: Serum neopterin concentration was measured in 198 patients with chronic heart failure (CHF) and 62 control subjects by ELISA. Patients were prospectively followed during a median follow-up period of 745 days with end points of cardiac death or re-hospitalization due to progressive heart failure. Serum concentration of neopterin increased with advancing New York Heart Association (NYHA) functional class (P < 0.001). High neopterin group had a significantly higher incidence of cardiac events than low neopterin group (P < 0.0001). In the multivariate Cox analysis, serum neopterin concentration was an independent risk factor for cardiac events (hazard ratio 1.70, 95%CI 1.16-2.50, P = 0.0068). Serum neopterin concentration is a novel prognostic marker for CHF.
Publisher: Elsevier Ireland Ltd
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/125
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/125/1/IntJCardiol_SasakiT.pdf
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2009.11.042
PubMed ID: 20051294
Other version: http://dx.doi.org/10.1016/j.ijcard.2009.11.042
Rights: Copyright © 2009 Elsevier Ireland Ltd All rights reserved.
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IntJCardiol_SasakiT.pdf103.58 kBAdobe PDFDownload

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