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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
A 医学部 = School of Medicine >
a10 学術雑誌論文等 = Journal Article >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/124
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| タイトル: | High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice |
| その他のタイトル: | HMGB1 restores cardiac function after MI |
| 著者: | Kitahara, Tatsuro
Takeishi, Yasuchika
Harada, Mutsuo
Niizeki, Takeshi
Suzuki, Satoshi
Sasaki, Toshiki
Ishino, Mitsunori
Bilim, Olga
Nakajima, Osamu
Kubota, Isao |
| 学内所属: | 循環器・血液内科学講座 |
| 誌名/書名: | Cardiovascular Research |
| 巻: | 80 |
| 号: | 1 |
| 開始ページ: | 40 |
| 終了ページ: | 46 |
| 発行日: | 2008年10月1日 |
| 抄録: | Aim: High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein and is released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. To test the hypothesis that HMGB1 enhances angiogenesis and restores cardiac function after myocardial infarction, we generated transgenic mice with cardiac specific overexpression of HMGB1 (HMGB1-Tg) using α-myosin heavy chain (MHC) promoter. Methods and Results: The left anterior descending coronary artery was ligated in HMGB1-Tg and wild-type littermate (Wt) mice. After coronary artery ligation, HMGB1 was released into circulation from the necrotic cardiomyocytes of HMGB1 overexpressing hearts. The size of myocardial infarction was smaller in HMGB1-Tg than in Wt mice. Echocardiography and cardiac catheterization demonstrated that cardiac remodeling and dysfunction after myocardial infarction were prevented in HMGB1-Tg mice compared to Wt mice. Furthermore, survival rate after myocardial infarction of HMGB1-Tg mice was higher than that of Wt mice. Immunohistochemical staining revealed that capillary and arteriole formations after myocardial infarction were enhanced in HMGB1-Tg mice. Conclusions: We demonstrated the first in vivo evidence that HMGB1 enhances angiogenesis, restores cardiac function, and improves survival after myocardial infarction. These results may provide a novel therapeutic approach for left ventricular dysfunction after myocardial infarction. |
| 出版者: | Oxford University Press |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/124 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/124/1/CardiovascRes_80_p40.pdf |
| ISSN: | 0008-6363 |
| DOI: | 10.1093/cvr/cvn163 |
| PubMed番号: | 18558628 |
| 異版(出版者版等): | http://dx.doi.org/10.1093/cvr/cvn163 |
| 権利情報: | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [Cardiovascular Research] following peer review. The definitive publisher-authenticated version [Cardiovascular Research 2008 Oct 1;80(1):40-46] is available online at: http://dx.doi.org/10.1093/cvr/cvn163 |
| 出現コレクション: | a10 学術雑誌論文等 = Journal Article
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