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Title: Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure
Other Titles: Plasma pentraxin 3 in heart failure
Authors: Suzuki, Satoshi
Takeishi, Yasuchika
Niizeki, Takeshi
Koyama, Yo
Kitahara, Tatsuro
Sasaki, Toshiki
Sagara, Mina
Kubota, Isao
Affiliation: 循環器・血液内科学講座
Source title: American Heart Journal
Volume: 155
Issue: 1
Start page: 75
End page: 81
Issue Date: Jan-2008
Abstract: Background: Pentraxin 3 (PTX3) is a novel inflammatory marker produced by endothelial cells, smooth muscle cells and macrophages. The purpose of the present study was to examine the clinical significance of plasma PTX3 levels in patients with heart failure. Methods: We measured plasma PTX3 levels in 196 patients with heart failure and 60 control subjects without heart failure by sandwich ELISA. Patients were prospectively followed during a median follow-up period of 655 days with the end points of cardiac death or progressive heart failure requiring re-hospitalization. Results: Plasma PTX3 concentrations were higher in patients with heart failure than in control subjects (P < 0.0001) and increased as the severity of NYHA functional class advanced (P < 0.0001). A total of 63 cardiac events occurred during a follow-up period, and cardiac event free rate was markedly lower in patients with high PTX3 levels than in those with normal PTX3 levels (44.7% vs. 89.2%, P < 0.0001). The multivariate Cox proportional hazard analysis demonstrated that plasma PTX3 level, but not high sensitive C-reactive protein, was the independent predictor of cardiac events (hazard ratio 1.20, 95% confidence interval 1.03-1.40, P = 0.0162). Patients were divided into 4 groups based on plasma PTX3 values from 1st to 4th quartile. The highest 4th quartile of plasma PTX3 levels was associated with the highest risk of cardiac events (9.23-fold compared to the 1st quartile). Conclusions: Plasma PTX3 level provides important prognostic information for the risk stratification of patients with heart failure.
Publisher: Mosby, Inc.
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/121
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/121/1/AmHeartJ_155_p75.pdf
ISSN: 0002-8703
1097-6744
DOI: 10.1016/j.ahj.2007.08.013
PubMed ID: 18082493
Other version: http://dx.doi.org/10.1016/j.ahj.2007.08.013
Rights: Copyright © 2008 Mosby, Inc. All rights reserved.
Appears in Collections:a10 学術雑誌論文等 = Journal Article

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