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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
A 医学部 = School of Medicine >
a10 学術雑誌論文等 = Journal Article >
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http://ir.fmu.ac.jp/dspace/handle/123456789/120
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| タイトル: | Linkage disequilibrium analyses of natriuretic peptide precursor B locus reveal risk haplotype conferring high plasma BNP levels |
| その他のタイトル: | NPPB SNP and plasma BNP |
| 著者: | Takeishi, Yasuchika
Toriyama, Sayumi
Takabatake, Noriaki
Shibata, Yoko
Konta, Tsuneo
Emi, Mitsuru
Kato, Takeo
Kawata, Sumio
Kubota, Isao |
| 学内所属: | 循環器・血液内科学講座 |
| 誌名/書名: | Biochemical and Biophysical Research Communications |
| 巻: | 362 |
| 号: | 2 |
| 開始ページ: | 480 |
| 終了ページ: | 484 |
| 発行日: | 2007年10月19日 |
| 抄録: | Background: Brain natriuretic peptide (BNP) has been widely used for the diagnosis and prognostic evaluation of chronic heart failure (CHF). In the present study, we performed association study of single nucleotide polymorphisms (SNPs) surrounding the natriuretic peptide precursor B (NPPB) gene with plasma BNP levels in 2970 adult Japanese. Methods and Results: Association analysis between SNPs of the NPPB gene and plasma BNP revealed significant associations of the 8 SNPs surrounding the entire NPPB gene with plasma BNP levels. For instance, as to SNP rs198389 (T-381C), plasma BNP levels among the three genotypic categories, i.e., 2189 homozygous T-allele carriers (BNP 26.4 + 0.6 pg/ml), 697 heterozygous carriers (35.0 + 1.1 pg/ml) and 52 homozygous C-allele carriers (46.0 + 4.1 pg/ml) indicated a co-dominant effect of the minor C-allele on elevating plasma BNP levels (P < 0.0001). Linkage disequilibrium (LD) analysis among the 8 SNPs revealed that the region consisted of two, 5’ major and 3’ minor, LD blocks. Haplotype-based association analysis demonstrated that plasma BNP levels were associated closely with the haplotypes-1 and -2 of the major LD block. Conclusion: These results suggest that genetic variation at the primary locus NPPB gene, represented by definition of risk haplotypes, may be an important determinant of plasma BNP levels. |
| 出版者: | Elsevier Inc. |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/120 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/120/1/BBRC_362_p480.pdf |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2007.08.028 |
| PubMed番号: | 17719005 |
| 異版(出版者版等): | http://dx.doi.org/10.1016/j.bbrc.2007.08.028 |
| 権利情報: | Copyright © 2007 Elsevier Inc. All rights reserved. |
| 出現コレクション: | a10 学術雑誌論文等 = Journal Article
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