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Title: Linkage disequilibrium analyses of natriuretic peptide precursor B locus reveal risk haplotype conferring high plasma BNP levels
Other Titles: NPPB SNP and plasma BNP
Authors: Takeishi, Yasuchika
Toriyama, Sayumi
Takabatake, Noriaki
Shibata, Yoko
Konta, Tsuneo
Emi, Mitsuru
Kato, Takeo
Kawata, Sumio
Kubota, Isao
Affiliation: 循環器・血液内科学講座
Source title: Biochemical and Biophysical Research Communications
Volume: 362
Issue: 2
Start page: 480
End page: 484
Issue Date: 19-Oct-2007
Abstract: Background: Brain natriuretic peptide (BNP) has been widely used for the diagnosis and prognostic evaluation of chronic heart failure (CHF). In the present study, we performed association study of single nucleotide polymorphisms (SNPs) surrounding the natriuretic peptide precursor B (NPPB) gene with plasma BNP levels in 2970 adult Japanese. Methods and Results: Association analysis between SNPs of the NPPB gene and plasma BNP revealed significant associations of the 8 SNPs surrounding the entire NPPB gene with plasma BNP levels. For instance, as to SNP rs198389 (T-381C), plasma BNP levels among the three genotypic categories, i.e., 2189 homozygous T-allele carriers (BNP 26.4 + 0.6 pg/ml), 697 heterozygous carriers (35.0 + 1.1 pg/ml) and 52 homozygous C-allele carriers (46.0 + 4.1 pg/ml) indicated a co-dominant effect of the minor C-allele on elevating plasma BNP levels (P < 0.0001). Linkage disequilibrium (LD) analysis among the 8 SNPs revealed that the region consisted of two, 5’ major and 3’ minor, LD blocks. Haplotype-based association analysis demonstrated that plasma BNP levels were associated closely with the haplotypes-1 and -2 of the major LD block. Conclusion: These results suggest that genetic variation at the primary locus NPPB gene, represented by definition of risk haplotypes, may be an important determinant of plasma BNP levels.
Publisher: Elsevier Inc.
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/120
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/120/1/BBRC_362_p480.pdf
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.08.028
PubMed ID: 17719005
Other version: http://dx.doi.org/10.1016/j.bbrc.2007.08.028
Rights: Copyright © 2007 Elsevier Inc. All rights reserved.
Appears in Collections:a10 学術雑誌論文等 = Journal Article

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