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Title: Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy
Authors: Takeishi, Yasuchika
Goto, Kaoru
Kubota, Isao
Affiliation: 循環器・血液内科学講座
Source title: Pharmacology & Therapeutics
Volume: 115
Issue: 3
Start page: 352
End page: 359
Issue Date: Sep-2007
Abstract: Diacylglycerol kinase (DGK) phosphorylates and converts diacylglycerol (DAG) to phosphatidic acid. DGK regulates cellular DAG levels and attenuates DAG signaling. The ten mammalian DGK isoforms have been identified to date. In cardiac myocytes, DGKα, ε, and ζ are expressed, and DGKζ is the predominant isoform. DGKζ inhibits protein kinase C activation and subsequent hypertrophic programs in response to endothelin-1 in neonatal rat cardiomyocytes. DGKζ blocks cardiac hypertrophy induced by G protein-coupled receptor agonists and pressure-overload in vivo. DGKζ attenuates ventricular remodeling and improves survival after myocardial infarction. These data provide a novel insight for subcellular mechanisms of cardiac hypertrophy and heart failure, and DGKζ may be a new therapeutic target to prevent cardiac hypertrophy and progression to heart failure.
Publisher: Elsevier Inc.
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/119
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/119/1/PharmacolTher_115_p352.pdf
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2007.04.010
PubMed ID: 17659347
Other version: http://dx.doi.org/10.1016/j.pharmthera.2007.04.010
Rights: Copyright © 2007 Elsevier Inc. All rights reserved.
Appears in Collections:a10 学術雑誌論文等 = Journal Article

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PharmacolTher_115_p352.pdf236.81 kBAdobe PDFDownload

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