DSpace Fukushima Medical University

福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
A 医学部 = School of Medicine >
a10 学術雑誌論文等 = Journal Article >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/118

Files in This Item:

File Description SizeFormat
JCardFail_13_p199.pdf207.18 kBAdobe PDFDownload
Title: High Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure
Other Titles: Serum pentosidine in heart failure
Authors: Koyama, Yo
Takeishi, Yasuchika
Arimoto, Takanori
Niizeki, Takeshi
Shishido, Tetsuro
Takahashi, Hiroki
Nozaki, Naoki
Hirono, Osamu
Tsunoda, Yuichi
Nitobe, Joji
Watanabe, Tetsu
Kubota, Isao
Affiliation: 循環器・血液内科学講座
Source title: Journal of Cardiac Failure
Volume: 13
Issue: 3
Start page: 199
End page: 206
Issue Date: Apr-2007
Abstract: Background: Pentosidine, one of the advanced glycation end products (AGE), is generated by nonenzymatic glycation and oxidation of proteins. The receptor of AGE (RAGE) is expressed in a variety of tissue, and interaction of AGE with RAGE induces oxidative stress and activation of intracellular signaling causing production of cytokines and mediators of inflammation. We investigated whether serum pentosidine is a risk factor for heart failure. Methods: Serum pentosidine concentration was measured in 141 patients with heart failure and 18 control subjects by a competitive enzyme-linked immunosorbent assay. Patients were prospectively followed during a median follow-up period of 479 days with endpoints of cardiac death or re-hospitalization. Results: Serum concentration of pentosidine was significantly higher in NYHA class III/IV patients than in NYHA class I/II patients (P < 0.0001). Serum pentosidine was also higher in patients with cardiac events than in event free patients (P < 0.001). In the univariate Cox proportional hazard analysis, age, NYHA class, pentosidine, creatinine, uric acid, B-type natriuretic peptide, left ventricular end-systolic volume and left ventricular mass were significant risk factors to predict cardiac events. In the multivariate Cox analysis, serum pentosidine concentration was an independent risk factor for cardiac events (hazard ratio 1.88, 95% confidence interval 1.23 . 2.69, P = 0.002). Patients were divided into 4 groups based on the serum pentosidine levels. The highest 4th quartile of pentosidine was associated with the highest risk of cardiac events (4.52-fold). Conclusions: Serum pentosidine concentration is an independent prognostic factor for heart failure, and this new marker may be useful for risk stratification of patients with heart failure.
Publisher: Elsevier Inc.
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/118
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/118/1/JCardFail_13_p199.pdf
ISSN: 1071-9164
DOI: 10.1016/j.cardfail.2006.11.009
PubMed ID: 17448417
Other version: http://dx.doi.org/10.1016/j.cardfail.2006.11.009
Rights: Copyright © 2007 Elsevier Inc. All rights reserved.
Appears in Collections:a10 学術雑誌論文等 = Journal Article

Files in This Item:

File Description SizeFormat
JCardFail_13_p199.pdf207.18 kBAdobe PDFDownload

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard