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Vol.65 (2019) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1059

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Title: Successful laparoscopic resection of virilizing ovarian steroid cell tumor, not otherwise specified, in a 22-year-old woman: a case report and evaluation of the steroidogenic pathway
Authors: Matsukawa, Jun
Takahashi, Toshifumi
Hada, Yurika
Kameda, Wataru
Ota, Kuniaki
Fukase, Mika
Takahashi, Kyoko
Matsuo, Koki
Mizunuma, Hideki
Nagase, Satoru
Affiliation: ふくしま子ども・女性医療支援センター
Source title: Fukushima Journal of Medical Science
Volume: 65
Issue: 3
Start page: 133
End page: 139
Issue Date: 2019
Abstract: Objective: Ovarian steroid cell tumor (SCT) is a rare tumor with steroid-producing ability. We report a 22-year-old woman with secondary amenorrhea and hirsutism caused by an ovarian SCT-not otherwise specified (NOS), who underwent successfully laparoscopic resection of the tumor. Case report: A 22-year-old null gravida woman presented to a hospital, having amenorrhea for 18 months and increasing facial hair. Physical examination revealed obesity (body mass index, 37.3 kg/m2) with evident facial and trunk hair. Total and free serum testosterone, and dehydroepiandrosterone sulfate levels were found to be elevated. Levels of serum adrenocorticotropic hormone, gonadotropins, cortisol, aldosterone, and ovarian steroids were observed to be within reference intervals. Although polycystic ovaries were not found, a hyperechogenic solid tumor (3 cm) was detected on transvaginal ultrasonography. Laparoscopic resection of the tumor was performed. One month post-surgery, total and free testosterone levels were observed to have decreased, and menstruation resumed two months thereafter. The patient was histologically diagnosed with ovarian SCT-NOS. Expression of ovarian steroidogenic enzymes, which are related to hyperandrogenism, was observed. No disease recurrence has been reported for more than 5 years post-surgery.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1059
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1059/1/FksmJMedSci_65_p133.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2019-25
PubMed ID: 31827013
Related Page: https://doi.org/10.5387/fms.2019-25
Rights: © 2019 The Fukushima Society of Medical Science
Appears in Collections:Vol.65 (2019)

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FksmJMedSci_65_p133.pdf2.67 MBAdobe PDFDownload

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