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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1056

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Title: Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis
Authors: Uekita, Hironori
Ishibashi, Toshiyuki
Shiomi, Masashi
Koyama, Hidenori
Ohtsuka, Shukuko
Yamamoto, Hiroshi
Yamagishi, Shoichi
Inoue, Hiroyoshi
Itabe, Hiroyuki
Sugimoto, Koichi
Kamioka, Masashi
Ohkawara, Hiroshi
Wada, Ikuo
Yasuchika, Takeishi
Affiliation: 循環器・血液内科学講座
細胞科学研究部門
Source title: Fukushima Journal of Medical Science
Volume: 65
Issue: 3
Start page: 109
End page: 121
Issue Date: 2019
Abstract: An advanced glycation end products (AGE)/a receptor for AGE (RAGE) axis plays a central role in the pathogenesis of diabetic vascular remodeling. This study was conducted to clarify the role of RAGE in nondiabetic atherosclerosis. We used the aortic and coronary atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbits prone to myocardial infarction (WHHLMI) at 1 to 14 months. Immunohistochemistry demonstrated the significant expression of RAGE as early as at 1 month with the stronger expression at 3 and 7 months, which was remarkably diminished at 14 months. RAGE expression was concordant with AGE accumulation. The major original sources of RAGE expression were macrophages and smooth muscle cells in addition to endothelial cells, and RAGE expression was distributed in the areas of phospholipid products, a component of oxidized LDL and nitrotyrosine. The concentrations of serum AGE did not alter significantly with aging. These findings suggested the expression of RAGE was induced by hyperlipidemia and oxidative stress independent of diabetes in WHHLMI rabbits. Additionally, our in vitro study showed that silencing of RAGE tended to attenuate oxidized-LDL-triggered PAI-1 expression in human cultured macrophages, as well as oxidized-LDL-induced tissue factor expression in peritoneal macrophages, suggesting a possible role of RAGE in prothrombogenic molecular regulation. In conclusion, the present study provides in vivo evidence that RAGE plays an integral role in the initiation and progression of nondiabetic atherosclerosis, suggesting that RAGE may be a novel target for treating not only diabetic but also nondiabetic vascular complications.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1056
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1056/1/FksmJMedSci_65_p109.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2019-12
PubMed ID: 31915324
Related Page: https://doi.org/10.5387/fms.2019-12
Rights: © 2019 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.65 (2019)

Files in This Item:

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FksmJMedSci_65_p109.pdf7.3 MBAdobe PDFDownload

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