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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.51 (2005) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/166
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| タイトル: | Effectiveness of intragastric immunization with protein and oligodeoxynucleotides containing a CpG motif for inducing a gastrointestinal mucosal immune response in mice |
| その他のタイトル: | Mucosal immunization with protein and CpG-DNA |
| 著者: | Hikichi, Takuto
Kobayashi, Hiroko
Oyama, Hitoshi
Yamamoto, Go
Watanabe, Hiroshi
Irisawa, Atsushi
Obara, Katsutoshi
Sato, Yukio |
| 学内所属: | 内科学第二講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 51 |
| 号: | 1 |
| 開始ページ: | 19 |
| 終了ページ: | 31 |
| 発行日: | 2005年6月 |
| 抄録: | PURPOSE: To investigate a new modality of mucosal vaccines, we evaluated the effectiveness of intragastric immunization for inducing a mucosal immune response in the gastrointestinal tract. METHODS: Mice were immunized with beta-galactosidase (beta-gal) and synthesized oligodeoxynucleotides containing a CpG motif (CpG-DNA) by intragastric injection, and the immune response was compared with those induced by 3 other immunization forms: intranasal, oral, and intradermal. RESULTS: Intragastric immunization with beta-gal and CpG-DNA induced significant anti-beta-gal fecal IgA production at 2 weeks; however, at 4 weeks the response was lacking. In contrast, intranasal immunization with beta-gal and CpG-DNA induced the highest anti-beta-gal fecal IgA production at 4 weeks. CONCLUSION: Although intragastric immunization with protein and CpG-DNA induces a mucosal immune response in the gastrointestinal tract, intranasal immunization is the most effective to induce both mucosal and systemic immune responses. This finding may increase the possibility for developing vaccines against mucosal pathogens, especially Helicobacter pylori. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/166 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/166/1/FksmJMedSci_51_p19.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.51.19 |
| PubMed番号: | 16167670 |
| 関連ページ: | https://doi.org/10.5387/fms.51.19 |
| 権利情報: | © 2005 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.51 (2005)
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