福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository

福島医大の震災レポート

Mon, 29 Aug 2011 22:58:59 GMT

タイトル: 福島医大の震災レポート

著者: 秋葉, さおり

誌名/書名: 医学図書館

巻: 58

号: 3

開始ページ: 205

終了ページ: 207

Prospective randomized comparative study of hemodynamic changes between ultrathin transnasal and conventional transoral esophagogastroduodenoscopy in percutaneous endoscopic gastrostomy placement with modified introducer method under sedation

Fri, 29 Oct 2010 22:58:59 GMT

タイトル: Prospective randomized comparative study of hemodynamic changes between ultrathin transnasal and conventional transoral esophagogastroduodenoscopy in percutaneous endoscopic gastrostomy placement with modified introducer method under sedation

著者: Suzuki, Rei; Hikichi, Takuto; Sato, Masaki; Takagi, Tadayuki; Ikeda, Tsunehiko; Watanabe, Ko; Nakamura, Jun; Irisawa, Atsushi; Obara, Katsutoshi; Ohira, Hiromasa

誌名/書名: Fukushima Journal of Medical Science

巻: 57

号: 1

開始ページ: 28

終了ページ: 32

抄録: AIM: Percutaneous Endoscopic Gastrostomy (PEG) placement is a useful but invasive method. Recently, the hemodynamic change of ultrathin transnasal esophagogastroduodenoscopy (transnasal EGD) was reported as less than that of conventional transoral EGD (transoral EGD). This study compared hemodynamic changes between transnasal EGD and transoral EGD in the setting of PEG placement using a modified Introducer method under sedation. METHODS: All 25 patients who were performed PEG in our hospital during the period December 2007 to February 2009 were enrolled in this study. We assigned them randomly to one of two groups, Group A for transoral EGD and Group B transnasal EGD. For both groups, the modified Introducer method was used. Vital signs (systolic blood pressure; SBP, heart rate; HR and rate pressure product; RPP) were monitored before and after scope insertion. RESULTS: We assigned 13 patients to Group A and 12 patients to Group B. The mean age was 69.4 years old in Group A and 69.8 in Group B. After scope insertion, mean changes of vital signs in Group A and B were, respectively, 17.8 mmHg and 17.3 mmHg in SBP, 12.1 bpm and 5.08 bpm in HR, and 25.9 and 17.5 in RPP. CONCLUSION: No significant differences of hemodynamic changes were seen between transnasal EGD and transoral EGD for the PEG placement with modified Introducer method under sedation. Results show that both methods are tolerable and feasible for PEG placement.

Fluvastatin increases bone mineral density in postmenopausal women

Fri, 29 Oct 2010 22:58:59 GMT

タイトル: Fluvastatin increases bone mineral density in postmenopausal women

著者: Gotoh, Mituhiro; Mizuno, Kenji; Ono, Yoshiaki; Takahashi, Michihiko

誌名/書名: Fukushima Journal of Medical Science

巻: 57

号: 1

開始ページ: 19

終了ページ: 27

抄録: Although several studies have reported a lower risk of osteoporotic fracture in hypercholesterolemic patients (WHO IIa) treated with statin, longitudinal studies on the effects of statins on bone are lacking. The aim of the present study was to evaluate bone mineral density (BMD) and bone turnover changes induced by 3-year fluvastatin treatment in postmenopausal women. Twenty-eight consecutive postmenopausal non-diabetic, normotensive hypercholesterolemic women (64.0±3.6 years) were treated for 36 months with 30 mg/day fluvastatin and 28 non-diabetic, normotensive normocholesterolemic age- and body mass index-matched postmenopausal women served as the control subjects. The result revealed a significant increase of the BMD as compared with the level at the base line (p< 0.001) in the fluvastairn-treated group, from 6 months on ward after the start treatment. Significant differences of the BMD were found between the controls and fluvastatin-treated group (p< 0.001) were at 6, 12, 24 and 36 months after the start of the study. In conclusion our results, although obtained small sample of postmenopausal hypercholesterolemic women, suggest a probable favorable effect of fluvastatin on bone formation and BMD.

Effect of methotrexate on fracture healing

Fri, 29 Oct 2010 22:58:59 GMT

タイトル: Effect of methotrexate on fracture healing

著者: Satoh, Koichiro; Mark, Hans; Zachrisson, Peter; Rydevik, Björn; Byröd, Gunnar; Kikuchi, Shin-Ichi; Konno, Shin-Ichi; Sekiguchi, Miho

誌名/書名: Fukushima Journal of Medical Science

巻: 57

号: 1

開始ページ: 11

終了ページ: 18

抄録: Low doses of methotrexate (MTX) are safe and effective for treating adult and juvenile rheumatoid arthritis. However, because this powerful anti-inflammatory drug might negatively influence the healing of wounds and fractures, MTX administration is often stopped during surgical procedures. The present study assesses the effects of low- and high-dose MTX on early inflammatory processes and bone healing in an experimental model of fracture.Thirty male Sprague-Dawley rats were assigned to low- and high-dose MTX and control groups. A femur was cut using a reciprocating saw and a 2-mm fracture gap was made using a fixator. One or four weeks thereafter, macrophages were immunostained and new bone formation was histomorphometrically measured.Significantly less new bone was formed in the high-dose MTX, than in the control group (p< 0.01), whereas bone formation did not significantly differ between the low-dose MTX and control groups. These results suggested that a low dose of MTX does not affect the early process of endochondral bone formation during fracture healing, whereas a high dose might delay the progress of new periosteal bone formation. Although more macrophages were found in the groups treated with MTX, their impact on surrounding inflammatory processes remains unclear.

Reinfection of cytomegalovirus in renal transplantation

Fri, 29 Oct 2010 22:58:59 GMT

タイトル: Reinfection of cytomegalovirus in renal transplantation

著者: Ishibashi, Kei; Yamaguchi, Osamu; Suzutani, Tatsuo

誌名/書名: Fukushima Journal of Medical Science

巻: 57

号: 1

開始ページ: 1

終了ページ: 10

抄録: Cytomegalovirus (CMV) is the most important pathogen affecting the outcome of renal transplantation. Reinfection of CMV can occur in CMV-seropositive donors and CMV seropositive recipients (D+/R+) settings because the protection against CMV conferred by preexisting immunity is limited due to its strain-dependent immune responses. To analyze the influence of CMV reinfection in renal transplantation, ELISA using fusion proteins encompassing epitope of glycoprotein H(gH) from both AD169 and Towne strains was employed before transplantation. The CMV-gH seropositive rate increased with increases in age and the rate of samples which contained antibodies against both AD169 and Towne were significantly high in the age of 50 years or over. Antibodies from HLA-DR10 and DR11 were associated with a significantly lower response rate against CMV-gH. In renal transplantation, the high degrees of antigenemia and high incidences of CMV disease are more prevalent in the CMV gH antibody-mismatched group in D+/R+ setting. The nucleotide sequence of the region of the gH epitope in the CMV-DNA extracted from the transplant recipients who showed high degree of antigenemia revealed the CMV reinfection from the donors. As a CMV indirect effect, the incidence of acute rejection in the mismatched gH antibody group was higher than that observed in the matched and D+/R- groups. The adverse events were more likely to occur in cases of D+/R+ renal transplantation with mismatched strain-specific antibodies which would indicates the risk of CMV reinfection after transplantation.

A 10-year-old girl with IgA nephropathy who 5 years later developed the characteristic features of henoch-schönlein purpura nephritis

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: A 10-year-old girl with IgA nephropathy who 5 years later developed the characteristic features of henoch-schönlein purpura nephritis

著者: Chishiki, Mina; Kawasaki, Yukihiko; Kaneko, Mariko; Ushijima, Yumiko; Ohara, Shinichiro; Abe, Yusaku; Suyama, Kazuhide; Hashimoto, Koichi; Hosoya, Mitsuaki

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 157

終了ページ: 161

抄録: We report a patient who developed Henoch-Schönlein purpura (HSP) 5 years after she presented with immunoglobulin A nephropathy (IgAN). A 10-year-old Japanese female was identified with proteinuria and hematuria by a school urinary screening. The first renal biopsy showed mesangial proliferative glomerulonephritis with immunofluorescent findings consistent with IgAN. She was treated with prednisolone, warfarin, and dilazep dihydrochloride, and the proteinuria and hematuria disappeared 4 months after the onset of treatment. Five years later she developed abdominal pain, gross hematuria and a classic purpuric rash of HSP after acute pharyngitis. The second renal biopsy showed diffuse mesangial proliferation with cellular crescent formation, and the patient was treated with methylprednisolone pulse therapy, prednisolone and mizoribine, resulting in a gradual decrease in urinary protein excretion. Our patient is unusual in that she developed Henoch-Schönlein purpura nephritis 5 years after clinical and biopsy evidence of IgAN, which suggests that IgAN and HSP are different clinical manifestations of the same disease, probably sharing a common pathogenesis.

A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation

著者: Ogawa, Kazuei; Ikeda, Kazuhiko; Furukawa, Miki; Harada-Shirado, Kayo; Mashimo, Yumiko; Takahashi, Hiroshi; Matsumoto, Hayato; Kimura, Satoshi; Shichishima-Nakamura, Akiko; Ohkawara, Hiroshi; Hashimoto, Yuko; Asahi, Koichi; Noji, Hideyoshi; Ohto, Hitoshi; Takeishi, Yasuchika

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 151

終了ページ: 156

抄録: Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema. We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing high-dose chemotherapy followed by autologous peripheral blood stem-cell transplantation (auto-PBSCT). The patient was a man aged in his 50s who had developed nephrotic syndrome. Bone marrow aspiration and kidney biopsy determined that the cause of the nephrotic syndrome was renal amyloidosis due to multiple myeloma, and the patient was admitted to our department in July 2003. After one course of chemotherapy, auto-PBSCT was performed in March 2004. Following transplantation, serum M-protein was no longer detectable from March 2005, and the patient achieved complete hematological remission. Subsequently, proteinuria decreased, serum albumin levels normalized, and nephrotic syndrome improved. As of 6 years after transplantation, in March 2010, the patient remained in remission, meaning that auto-PBSCT proved extremely effective as a treatment for renal amyloidosis in this case.

A case of primary malignant lymphoma of the breast with an unusual ultrasound image

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: A case of primary malignant lymphoma of the breast with an unusual ultrasound image

著者: Matsuzaki, Masami; Nomizu, Tadashi; Katagata, Naoto; Sakuma, Takeshi; Momma, Tomoyuki; Tachibana, Kazunoshin; Andoh, Jin; Watanabe, Fumiaki; Yamaguchi, Yoshiko; Nihei, Mitsuhiro

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 145

終了ページ: 150

抄録: The patient was a 50-year-old woman with a palpable tumor and pain in the right breast in May of 2008. The tumor was then diagnosed as an atheroma. The tumor enlarged rapidly in June, and the pain and the redness had worsened. The patient was then referred to our hospital. The tumor was in the upper inner quadrant of the right breast with surface redness, measuring about 3 cm. In the mammographic (MMG) findings, the tumor shadow was in the upper inner quadrant of the right breast and was observed to be circular and have a high density with a plain boundary and slightly roughed edges. In the ultrasonographic (US) findings, an oval-shaped high echoic region was found subcutaneously in the right breast. Because the high echoic area was subdivided in the partition of the low echoic string, it looked like a pebbled wall. Upon core needle biopsy, this case was diagnosed as malignant lymphoma. After comparing the histopathology and the US image, it was determined that the pebbled wall-shaped image was due to lymphocyte infiltration of the tissue. The US image was peculiar and we report this case as a peculiar example of malignant lymphoma.

Survival of a refractory ventricular fibrillation by cooperative treatments

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: Survival of a refractory ventricular fibrillation by cooperative treatments

著者: Tase, Choichiro; Ohno, Yuko; Hasegawa, Arifumi; Tsukada, Yasuhiko; Shimada, Jiro; Ikegami, Yukihiro; Sakamoto, Nobuo; Takeishi, Yasuchika

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 139

終了ページ: 143

抄録: In the case of acute myocardial infarction (AMI), prompt and appropriate initial treatment is essential for increasing the rate of survival and early reperfusion is a main determinant factor for long-term prognosis. The survival of a patient with refractory ventricular fibrillation was made possible by cooperative emergency medical care including air medical transport, despite long distance to the hospital. The patient was a 60-year-old man. Under a diagnosis of AMI, a helicopter emergency medical service (HEMS) with medical staff on board was requested. Although ventricular fibrillation (VF) occurred at the scene, quick and appropriate advanced cardiovascular life support (ACLS) was provided by the attending doctor, leading to the return of heartbeat. Since the patient still exhibited serious bradycardia and cardiac failure, he was airlifted while undergoing transcutaneous pacing. Upon arrival at the hospital, the patient underwent emergency percutaneous coronary intervention (PCI). During the PCI, VF recurred and chest compressions and a total of 17 defibrillations were performed. The PCI was continued with percutaneous cardiopulmonary support (PCPS). The patient survived without sequelae. Smoother cooperation between pre-hospital medical procedures and post-hospital emergency care is considered to be essential for the survival of patients such as this case.

Effects of oral supplementation of L-arginine in the treatment of pulmonary hypertension secondary to pulmonary embolism: a case report

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: Effects of oral supplementation of L-arginine in the treatment of pulmonary hypertension secondary to pulmonary embolism: a case report

著者: Ogata, Hiroshi; Takahashi, Tomoko; Ishikawa, Kazunobu; Ishibashi, Tosiyuki; Maruyama, Yukio; Watanabe, Machiko; Edo, Kiyoto

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 135

終了ページ: 138

抄録: We tried L-arginine for the treatment of pulmonary hypertension secondary to pulmonary embolism. The plasma brain natriuretic peptide (BNP) level inversely correlated with the plasma concentration of L-arginine. After oral supplementation of L-arginine, patient's symptoms (shortness of breath and general malaise), state of congestive heart failure, and exercise capacity all improved. L-arginine may be effective in the treatment of pulmonary hypertension secondary to pulmonary embolism.

Two cases of acute atraumatic compartment syndrome complicated with severe heat stroke

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: Two cases of acute atraumatic compartment syndrome complicated with severe heat stroke

著者: Ikegami, Yukihiro; Hasegawa, Arifumi; Tsukada, Yasuhiko; Abe, Yoshinobu; Shimada, Jiro; Tase, Choichiro

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 129

終了ページ: 133

抄録: Acute compartment syndrome is a life-threatening complication in trauma patients. Not only regional neuromuscular disability, but also systemic organ disorders can result from prolonged tissue ischemia. In this report, we describe 2 cases of acute atraumatic compartment syndrome complicated with severe heat stroke. In both cases, emergency fasciotomy was rapidly performed after recognition of the syndrome, but serious regional neuromuscular disabilities remained. Microvascular endothelial injury is an important mechanism of acute atraumatic compartment syndrome. Thrombi diffusely formed in the compartmental space hinder establishment of reperfusion even after fasciotomy. Furthermore, disruption of fibrinolysis due to heat stroke could enhance this damage.

Therapy-related myelodysplastic syndrome following cyclophosphamide pulse and/or methotrexate therapy in a patient with systemic lupus erythematosus.

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: Therapy-related myelodysplastic syndrome following cyclophosphamide pulse and/or methotrexate therapy in a patient with systemic lupus erythematosus.

著者: Iwadate, Haruyo; Kobayashi, Hiroko; Yano, Kiori; Watanabe, Hiroshi; Ikeda, Kazuhiko; Ogawa, Kazuei; Ohira, Hiromasa

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 121

終了ページ: 127

抄録: A 27-year-old woman exhibited progressive pancytopenia during cyclophosphamide pulse therapy for lupus nephritis and low-dose methotrexate therapy for severe arthralgia. Bone marrow aspiration revealed highly abnormal cell morphology, indicating therapy-related myelodysplastic syndrome. Pancytopenia and bone marrow cell morphology improved 3 months after discontinuation of cyclophosphamide. It is necessary to promptly examine bone marrow cell morphology and chromosomal aberration in cases with connective tissue diseases complicated by sudden cytopenia during immunosuppressive therapy with chemotherapeutic agents.

Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome

著者: Yoshihisa, Akiomi; Owada, Takashi; Hoshino, Yasuto; Miyata, Makiko; Misaka, Tomofumi; Sato, Takamasa; Suzuki, Satoshi; Sakamoto, Nobuo; Sugimoto, Koichi; Kunii, Hiroyuki; Nakazato, Kazuhiko; Suzuki, Hitoshi; Saitoh, Shu-Ichi; Ishibashi, Toshiyuki; Takeishi, Yasuchika

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 115

終了ページ: 120

抄録: [Background] Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient. [Methods] Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36). [Results] There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01). [Conclusions] Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS.

Hematopoietic stem cell transplantation in the department of hematology, fukushima medical university

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: Hematopoietic stem cell transplantation in the department of hematology, fukushima medical university

著者: Ogawa, Kazuei; Noji, Hideyoshi; Furukawa, Miki; Harada-Shirado, Kayo; Mashimo, Yumiko; Takahashi, Hiroshi; Matsumoto, Hayato; Kimura, Satoshi; Shichishima-Nakamura, Akiko; Ohkawara, Hiroshi; Ikeda, Kazuhiko; Ohto, Hitoshi; Takeishi, Yasuchika

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 107

終了ページ: 114

抄録: From 1996 to the end of 2009, a total of 114 cases of hematopoietic stem cell transplantation were performed in the Department of Hematology, Fukushima Medical University. We report here a general overview of our results. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed in 37 cases of acute leukemia, 10 of myelodysplastic syndrome, 5 of aplastic anemia, and 5 others. The 5-year survival rate with allo-HSCT was 51.1%. Autologous hematopoietic stem cell transplantation (auto-HSCT) was performed in 34 cases of malignant lymphoma, 15 of multiple myeloma, and 8 others. The 5-year patient survival rate was 75.2% with malignant lymphoma and 46.7% with multiple myeloma. These results are comparable to those from a nationwide survey in Japan, confirming that our hospital has attained a creditable level as a transplantation center.

An electronic radial scanning echoendoscope is superior to a mechanical radial scanning echoendoscope in ultrasound image quality for gastrointestinal tract and pancreaticobiliary lesions

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: An electronic radial scanning echoendoscope is superior to a mechanical radial scanning echoendoscope in ultrasound image quality for gastrointestinal tract and pancreaticobiliary lesions

著者: Hikichi, Takuto; Irisawa, Atsushi; Takagi, Tadayuki; Shibukawa, Goro; Wakatsuki, Takeru; Imamura, Hidemichi; Takahashi, Yuta; Sato, Ai; Sato, Masaki; Ikeda, Tsunehiko; Suzuki, Rei; Watanabe, Ko; Nakamura, Jun; Ohira, Hiromasa; Obara, Katsutoshi

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 99

終了ページ: 106

抄録: [Purpose] To objectively compare the electronic radial scanning echoendoscope (ER-ES) with the mechanical radial scanning echoendoscope (MR-ES) in the quality of endoscopic ultrasonography (EUS) images of gastrointestinal tract and pancreaticobiliary lesions. [Methods] Studied were 56 patients: 20 with gastric cancer, 20 with gallbladder lesions, and 16 with intraductal papillary-mucinous neoplasms of the pancreas (IPMN). They were subjected to EUS, half of them using the ER-ES, and the other half using the MR-ES. EUS images thus obtained were evaluated concerning four items in patients with gastric cancer and those with gallbladder lesions, and three items in patients with IPMN. Six endosonographers blindly assessed two EUS images per patient on a visual analogue scale. In each of the three groups of patients, the evaluators' median scores for the ER-ES and MR-ES for each item were compared. [Results] The median scores for the ER-ES were significantly higher than those for the MR-ES in all items in patients with gastric cancer and those with IPMN, and in one item in patients with gallbladder lesions. [Conclusion] The ER-ES is certainly superior to the MR-ES in the quality of EUS images of gastrointestinal tract and pancreaticobiliary lesions.

The predictive factors for the resorption of a lumbar disc herniation on plain MRI

Sun, 28 Nov 2010 22:58:59 GMT

タイトル: The predictive factors for the resorption of a lumbar disc herniation on plain MRI

著者: Iwabuchi, Masumi; Murakami, Kazuya; Ara, Fumihiro; Otani, Koji; Kikuchi, Shin-Ichi

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 2

開始ページ: 91

終了ページ: 97

抄録: Previous studies have noted the morphologic changes of lumbar disc herniation (LDH) in conservative treatment and predictive value of the resorption of LDH by using contrast-enhanced MRI. However, there are few reports that note the predictive value of plain, non-enhanced MRI. Therefore, no definite predictive factors for the resorption of LDH have been detected on plain MRI. Thirty-four patients with lower limb pain receiving conservative treatment were followed for more than 6 months. MRI was performed every 3 months. The findings of the first MRI in the patients who finally had resorption of LDH (R-group, 21 patients) were compared with those of the patients who exhibited no resorption of LDH (N-group, 13 patients). The MRI evaluation included the signal intensity of LDH, migration of LDH. The transition of the visual analogue scale (VAS) of lower limb pain was also compared. The R-group had significantly more patients with iso-signal intensity in comparison to the signal intensity of the nucleus pulposus observed on T1 weighted images (WI) and high-signal intensity in comparison to the signal intensity of the annulus fibrosus observed on T2 WI, whereas the N-group had more patients with the high-signal intensity on both T1 and T2 WI. The R-group had significantly more patients with migration. The VAS significantly improved at 3 and 6 months in both groups. However, no statistically significant difference was detected between the 2 groups. It is very valuable that the results clearly indicate the predictive factors on plain MRI concerning the resorption of LDH. The study also showed that lower limb pain would gradually improve even in the patients who exhibited no resorption. Therefore, it is important in the treatment of LDH to observe the clinical symptoms carefully without overestimating MRI findings.

Association between maternal feeling about pregnancy and child's lifestyle

Sat, 29 May 2010 22:58:59 GMT

タイトル: Association between maternal feeling about pregnancy and child's lifestyle

著者: Saito, Tomoko; Goto, Aya; Yokokawa, Hirohide; Sato, Yoshiaki; Yasumura, Seiji

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 80

終了ページ: 89

抄録: The number of children with undesirable lifestyles has recently increased. We tested the hypothesis that maternal feelings about pregnancy might be associated with their attitude towards promoting healthy lifestyles in their children. We used a city database collected from guardians of 204 randomly selected children aged 1 to 3 years in Nihonmatsu City, Fukushima. Maternal feeling about pregnancy was measured using a 10-point scale, and a child lifestyle score was calculated as the sum of desirable lifestyle habits (sleeping, eating, watching TV/videos, and tooth brushing). Associations between maternal feeling and her child's lifestyles were examined with multiple logistic regression analysis. For all lifestyle items, proportion of children with undesirable lifestyle habits was higher in the "unhappy group" (those who scored 1 to 9) than in the "happy group" (those who scored 10). In particular, a child's short sleeping hours (odds ratio [OR]=3.01) and lifestyle score of less than 3 ([OR] =3.60) were significantly associated with unhappy feelings. This was apparent among mothers aged 29 (median age) or younger. Our results indicate an association between a mother's unhappy feelings about pregnancy and her child's undesirable lifestyle, especially among relatively younger mothers. These findings provide public health implications important for early familial intervention to improve children's lifestyles.

Helicopter emergency medical services (doctor-helicopter) in Fukushima Prefecture: present state and problems

Sat, 29 May 2010 22:58:59 GMT

タイトル: Helicopter emergency medical services (doctor-helicopter) in Fukushima Prefecture: present state and problems

著者: Tase, Choichiro; Ohno, Yuko; Hasegawa, Arifumi; Tsukada, Yasuhiro; Shimada, Jiro; Ikegami, Yukihiro

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 71

終了ページ: 79

抄録: The purpose of this study is to identify the problems in operating an emergency medical service helicopter with an emergency medicine doctor on board (doctor-helicopter) in Fukushima Prefecture, Japan, which covers wide regions and many rural areas. The study looked at the numbers of flights and patients during the 523 days since the start of the doctor-helicopter service at the Fukushima Medical University Hospital. The items investigated were: number of flights, number of helicopter dispatches per month, number of patients, the hospitals where patients were taken to, the fire department dispatch centers that requested the doctor-helicopter, and the number of times each doctor flew on the helicopter. There were 450 flights. When the service was started, there were a few flights, but they gradually increased. The majority of the flights were to emergency scenes (295), while 75 flights were interfacility transports of critically ill patients, 79 flights were cancelled after take-off, and one flight was for a disaster relief operation. The nature of requests differed greatly depending on the fire department dispatch center requesting the service. The majority of patients were trauma patients (62.2%). Stroke (8.5%) and acute coronary syndrome (5.2%) patients requiring emergency treatment were fewer than anticipated. The final destination hospitals were appropriate hospitals in the region. Because the number of flight doctors is small, the burden on individual doctors is large. A system for early on-site diagnosis and helicopter request by emergency rescue team is required to maintain a high quality of emergency care.

Epidemiology research training in Vietnam: evaluation at the five year mark

Sat, 29 May 2010 22:58:59 GMT

タイトル: Epidemiology research training in Vietnam: evaluation at the five year mark

著者: Goto, Aya; Vinih, Nguyen Quang; Van Nguyen, Thi Tu; Yokokawa, Hirohide; Yasumura, Seiji; Khue, Nguyen Thy

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 63

終了ページ: 70

抄録: Recently, the importance of research capacity development has been rediscovered as a vital approach to help strengthen health systems for improved global health. The University of Medicine and Pharmacy, Ho Chi Minh City (UMP) in Vietnam in collaboration with the Department of Public Health at the Fukushima Medical University School of Medicine (PHFMU) developed an epidemiology training course for mid-career Vietnamese physicians. We trained a total of 128 participants over four courses since 2004. In order to balance basic and advanced course content for first-time and returning participants, we encouraged active participation of past graduates in teaching Course IV in 2009. Not only did this provide further training opportunities for advanced learners, it also increased project ownership by Vietnamese participants. Although more rigorous evaluation is needed, we believe that this summary of our past activities presents a useful example for others undertaking similar initiatives. To further upgrade the project in Vietnam, institutional support is required to nurture a strong scientific emphasis as well as self-sustainability in research capacity development.

Diabetic mastopathy in an elderly woman: a case report

Sat, 29 May 2010 22:58:59 GMT

タイトル: Diabetic mastopathy in an elderly woman: a case report

著者: Tsuchiya, Atsuo; Tsunoda, Rikiya; Seino, Kageyoshi; Akuzawa, Kazuo

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 57

終了ページ: 62

抄録: We report a case of diabetic mastopathy in an elderly woman with type II diabetes. The patient, a 66-year-old woman with a 6-year history of diabetes mellitus, has been received an oral diabetic agent. She noticed a lump in her right breast two months previously. Mammography of the breast showed a low density mass, but there was no microcalcification or architectural distortion. Ultrasonography of the lesion revealed a hypoechoic mass with a distinct margin. Fine needle aspiration cytology was performed but sufficient tissue was not obtained. However, a cluster of small epithelial cells with nucleus swelling and increased chromatin was demonstrated. Excisional biopsy was performed and diabetic mastopathy was demonstrated histologically.

A case of Henoch-Schoenlein purpura nephritis recurring after 3 years remission

Sat, 29 May 2010 22:58:59 GMT

タイトル: A case of Henoch-Schoenlein purpura nephritis recurring after 3 years remission

著者: Ushijima, Yumiko; Kawasaki, Yukihiko; Kaneko, Mariko; Haneda, Kentaro; Sakai, Nobuko; Suyama, Kazuhide; Hashimoto, Koichi; Hosoya, Mitsuaki

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 50

終了ページ: 56

抄録: Henoch-Schoenlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries with IgA immune complexes deposition, and about 7% of patients with HSP experience recurrence. Most patients with recurring of HSP nephritis show a recurrence of clinical symptoms over a period ranging from 2 to 5 months, even after the disappearance of initial symptoms. Here we report a 9-year-old girl diagnosed with recurrent HSP and severe crescentic glomerulonephritis 3 years after complete resolution of the initial symptoms of HSP. Our case is unique in respect of the recurrence at more than 3 years after the complete resolution of initial symptoms, suggesting that careful followup is required in spite of improved renal symptoms in cases of HSP.

A case of congenital unilateral partial absence of fallopian tube

Sat, 29 May 2010 22:58:59 GMT

タイトル: A case of congenital unilateral partial absence of fallopian tube

著者: Yazawa, Hiroyuki; Yabe, Michihiro; Endo, Sumiko; Hayashi, Syoutaro

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 44

終了ページ: 49

抄録: Congenital partial absence of a fallopian tube has rarely been reported in the literature. A 29-year-old nulligravida woman presented with a two-year history of infertility. Hysterosalpingography revealed an obstructed left fallopian tube with a normal uterine cavity and right fallopian tube. After several AIH treatments, diagnostic laparoscopy was performed, revealing segmental absence of the mid portion of the left fallopian tube. Only a 1-cm stump of the left fallopian tube remained, the majority of the isthmic portion was absent. A 3-cm distal ampullary portion with normal-appearing fimbria was attached to the left pelvic sidewall near the pelvic brim. No other abnormal findings were observed for the uterus, right fallopian tube, and ligaments surrounding the uterus. There are two possible etiologies of partial absence of the fallopian tube:congenital absence associated with developmental alterations of the Müllerian ducts or asymptomatic torsion followed by autoamputation and reabsorption.

Schwannoma of the gallbladder: report of a case

Sat, 29 May 2010 22:58:59 GMT

タイトル: Schwannoma of the gallbladder: report of a case

著者: Ohta, Ryo; Hirata, Yudai; Oneyama, Masataka; Takahashi, Yasumasa; Kawahara, Yuichi; Kitamura, Masaya; Goto, Manabu; Sekikawa, Koji; Takenoshita, Seiichi

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 38

終了ページ: 43

抄録: We report a schwannoma of the gallbladder in a 58-year-old man who was diagnosed as cholecystolithiasis. He presented with recurrent episodes of abdominal pain in the right upper quadrant. The abdominal computed tomography scan and ultrasonography revealed stones about 15 mm in diameter in the gallbladder. Under the diagnosis of cholecystolithiasis, laparoscopic cholecystectomy was performed. The resected specimen showed chronic cholecystitis and no suspicion of neoplasm. Pathological examination revealed that the tumor consist of spindle cells without atypical appearance at small area of fundus. Immunohistologically, tumor cells were positive for S-100 protein and negative for alpha-SMA and c-kit, the lesion was diagnosed as schwannoma.

Non-antibiotic treatment for pediatric outpatients with common cold inhibits the emergence of drug resistant pneumococci

Sat, 29 May 2010 22:58:59 GMT

タイトル: Non-antibiotic treatment for pediatric outpatients with common cold inhibits the emergence of drug resistant pneumococci

著者: Matsumoto, Ayumi; Takeyama, Aya; Hashimoto, Koichi; Ito, Masaki; Katayose, Masahiko; Kato, Kazuo; Kawasaki, Yukihiko; Hosoya, Mitsuaki

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 28

終了ページ: 37

抄録: The occurrence of drug resistant Streptococcus pneurmoniae (S. pneumoniae) is very high in Japan. Unnecessary use of antibiotics had been thought to cause this problem but previous studies had not clearly showed that the decreasing rate of antibiotic use had been related to the reduction of the prevalence of resistant strains. In this study, we tried to prove that non-antibiotic treatment for common cold would reduce the antibiotic resistant S. pneumoniae in nasopharynx in children. Forty-five children with the common cold were randomly selected from pediatric patients who had taken antibiotics within the past three months. We collected nasopharyngeal swabs from all of the participants and once again after a period of 2 to 3 months without using any antibiotics. Twenty-four of these patients had the S. pneumoniae strains isolated. Then these strains were undergone a susceptibility test and drug-resistant gene detection. The susceptibility test reveled that patients with penicillin-resistant strains decreased from 17 to 7 (p < 0.01). The test also reveled that the decreased number of patients had strains that were resistant to cefditren. The gene detection revealed that none of the patients acquired a higher resistance to penicillin. Our study suggests that the treatment without antibiotics reduces the drug-resistant S. pneumoniae. Controlled antibiotic use in children might prevent children from carrying the antibiotic resistant S. pneumoniae.

No inhibitory effects of (-)-epigallocatechin gallate and lycopene on spontaneous hepatotumorigenesis in C3H/HeN mice

Sat, 29 May 2010 22:58:59 GMT

タイトル: No inhibitory effects of (-)-epigallocatechin gallate and lycopene on spontaneous hepatotumorigenesis in C3H/HeN mice

著者: Takahashi, Yoshihisa; Hara, Yukihiko; Imanaka, Masayo; Wanibuchi, Hideki; Tanaka, Kiyoji; Ishikawa, Takatoshi; Mori, Shigeo; Fukusato, Toshio

誌名/書名: Fukushima Journal of Medical Science

巻: 56

号: 1

開始ページ: 17

終了ページ: 27

抄録: Although several studies have indicated that (-)-epigallocatechin gallate (EGCG) and lycopene, representative dietary antioxidants, inhibit chemically induced animal tumorigenesis, only a few studies have examined the inhibitory effects of these compounds on spontaneous liver tumorigenesis in rodents. In this study, we investigated the inhibitory effects of these compounds on the formation of spontaneous liver tumors in C3H/HeN mice. We used xeroderma pigmentosum group A (XPA) gene-deficient mice to simultaneously examine whether the knockout mice could be used as a sensitive animal model. Inaddition, we examined the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG)--a marker of reactive oxygen species-induced DNA injury--in liver tissue. Male XPA +/+, XPA +/-, and XPA -/- mice with a C3H/HeN genetic background were divided into 3 groups: control, EGCG, and lycopene. Autopsy at 18 months of age revealed that EGCG and lycopene did not exhibit obvious suppressive effects on the development of liver tumors in any XPA genotype; further, the XPA genotype did not influence any susceptibility to liver tumors. With regard to 8-OHdG levels in non-tumorous liver tissue at 8 months of age, EGCG showed no significant inhibitory effects and lycopene showed significant inhibitory effects only in XPA +/- mice. The present study demonstrates that contrary to previous reports of the inhibitory effects of EGCG and lycopene on the development of various carcinogen-induced animal tumors, these compounds exert no chemopreventive effects on spontaneous liver tumorigenesis in C3H/HeN mice. EGCG and lycopene may inhibit carcinogen-induced tumors through properties other than their antioxidant abilities.